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Salicylhydroxamic Acid Inhibits the Growth of Candida albicans

Citation

Pang, SM and Tristram, S and Brown, S, Salicylhydroxamic Acid Inhibits the Growth of Candida albicans, International Journal of Biological and Life Sciences, 7, (1) pp. 40-46. ISSN 2073-0527 (2011) [Refereed Article]


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Copyright Statement

Copyright 2011 World Academy of Science, Engineering and Technology

Official URL: http://www.waset.org/journals/ijbls/v7.php

Abstract

Candida spp. are common and aggressive pathogens. Because of the growing resistance of Candida spp. to current antifungals, novel targets, found in Candida spp. but not in humans or other flora, have to be identified. The alternative oxidase (AOX) is one such possibility. This enzyme is insensitive to cyanide, but is sensitive to compounds such as salicylhydroxamic acid (SHAM), disulfiram and n-alkyl gallates. The growth Candida albicans was inhibited by SHAM (Ki = 9-15 mM) and cyanide (Ki = 2-4 mM), albeit to differing extents. The rate of O2 uptake was inhibited by less than 10% by 25 mM SHAM and by about 90% by 250 ýM KCN. Although SHAM substantially inhibited the growth of C. albicans, it is unlikely that the inhibition of AOX was the cause. Salicylhydroxamic acid is used therapeutically in the treatment of urinary tract infections and urolithiasis, but it also has some potential in the treatment of C. albicans infection.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Medical Microbiology
Research Field:Medical Infection Agents (incl. Prions)
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Infectious Diseases
Author:Pang, SM (Ms Pang)
Author:Tristram, S (Dr Stephen Tristram)
Author:Brown, S (Dr Simon Brown)
ID Code:75733
Year Published:2011
Deposited By:Health Sciences A
Deposited On:2012-02-13
Last Modified:2012-08-08
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