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High Serum Erythropoietin and Ferritin Levels in Conjunction with Anemia Response in Malignant Lymphoma


Omari, SAM and Khalafallah, A and Ayesh, M and Matalka, I and Al-Hadithi, R, High Serum Erythropoietin and Ferritin Levels in Conjunction with Anemia Response in Malignant Lymphoma, Mediterranean Journal of Hematology and Infectious Diseases, 3, (1) Article e2011018. ISSN 2035-3006 (2011) [Refereed Article]


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Licensed under Creative Commons Attribution 2.0 Generic (CC BY 2.0)

DOI: doi:10.4084/MJHID.2011.018


Anemia is a common finding in lymphoma. There are few data available regarding the erythropoietin (EPO) levels in conjunction with ferritin in lymphoma patients. We prospectively evaluated 55 patients diagnosed with malignant lymphoma during the period between November 2006 and March 2008 at the King Abdullah University Teaching Hospital, Jordan. Our data showed that 74.4% of lymphoma patients were anemic. Furthermore, serum EPO and ferritin levels were higher in lymphoma patients compared with the healthy controls (P=0.001). The observed versus predicted EPO ratio showed also significantly higher levels in anemic lymphoma patients compared to healthy controls (p=0.03). There was an improvement in the Hb level in lymphoma patients who were treated with at least 3-cycles of chemotherapy as compared with newly-diagnosed patients. An adequate increase of EPO levels was observed in anemic lymphoma patients and notably associated with higher ferritin levels and improvement of Hb (p<0.001).Our findings suggest that ferritin estimation in lymphoma patients may predict the level of erythropoiesis and possibly the degree of anemia. Further studies to confirm these findings are warranted.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Oncology and carcinogenesis
Research Field:Solid tumours
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Omari, SAM (Dr Sofia Omari)
UTAS Author:Khalafallah, A (Professor Alhossain Khalafallah)
ID Code:75671
Year Published:2011
Deposited By:Health Sciences A
Deposited On:2012-02-09
Last Modified:2017-10-30
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