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Altered glycosylation of acetylcholinesterase in lumbar cerebrospinal fluid of patients with Alzheimer's disease
Citation
Saez-Valero, J and Barquero, MS and Marcos, A and McLean, CA and Small, DH, Altered glycosylation of acetylcholinesterase in lumbar cerebrospinal fluid of patients with Alzheimer's disease, Journal of Neurology, Neurosurgery and Psychiatry, 69, (5) pp. 664-667. ISSN 0022-3050 (2000) [Refereed Article]
DOI: doi:10.1136/jnnp.69.5.664
Abstract
As clinical diagnosis of Alzheimer's disease is only 80%-90% accurate, there is a need to identify biochemical markers of Alzheimer's disease. Previous studies have shown an abnormality in the glycosylation of acetylcholinesterase (AChE) in the CSF collected postmortem from patients with Alzheimer's disease. This abnormality was very specific for Alzheimer's disease, as it was not detected in other illnesses causing dementia. We report here that the glycosylation of AChE is also altered in lumbar CSF collected antemortem. The altered glycosylation was due to increased concentrations of a minor AChE isoform that does not bind to concanavalin A (Con A). Glycosylation of AChE may eventually be of diagnostic value, especially when used in combination with other CSF markers.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Neurosciences |
| Research Field: | Neurosciences not elsewhere classified |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Clinical health not elsewhere classified |
| UTAS Author: | Small, DH (Professor David Small) |
| ID Code: | 75364 |
| Year Published: | 2000 |
| Web of Science® Times Cited: | 39 |
| Deposited By: | Research Division |
| Deposited On: | 2012-01-25 |
| Last Modified: | 2012-01-25 |
| Downloads: | 0 |
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