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Acetylcholinesterase and butyrylcholinesterase glycoforms are biomarkers of Alzheimer's disease

Citation

Saez-Valero, J and Small, DH, Acetylcholinesterase and butyrylcholinesterase glycoforms are biomarkers of Alzheimer's disease, Journal of Alzheimer's Disease, 3, (3) pp. 323-328. ISSN 1387-2877 (2001) [Refereed Article]

DOI: doi:10.3233/JAD-2001-3307

Abstract

The identification of a biochemical marker in cerebrospinal fluid (CSF) that can discriminate between Alzheimer's disease (AD) and other dementia-causing diseases would be a major advance. Our previous studies have shown that the glycosylation of acetylcholinesterase (AChE) is altered in the post mortem brain and cerebrospinal fluid of AD patients. We have also found that the glycosylation of AChE is altered in lumbar CSF collected ante mortem. The change in glycosylation of AChE is very specific for AD and is not seen in many other neurological diseases including other dementias. The sensitivity of detection of AD using AChE glycosylation (60-80%) is lower than that considered necessary for a satisfactory diagnostic marker. However, more recently we have found that the glycosylation of the related enzyme butyrylcholinesterase (BuChE) is also altered in AD CSF. By combining the analysis of AChE glycosylation with that of BuChE glycosylation, improved sensitivity of detection is obtained. We propose that AChE and BuChE glycosylation may be of diagnostic value, especially when used in combination with other CSF markers such as Aβ or tau.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Neurosciences not elsewhere classified
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Neurodegenerative Disorders Related to Ageing
UTAS Author:Small, DH (Professor David Small)
ID Code:75363
Year Published:2001
Web of Science® Times Cited:8
Deposited By:Research Division
Deposited On:2012-01-25
Last Modified:2012-01-25
Downloads:0

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