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An unusually glycosylated form of acetylcholinesterase is a CSF biomarker for Alzheimer's disease

Citation

Saez-Valero, J and Mok, SS and Small, DH, An unusually glycosylated form of acetylcholinesterase is a CSF biomarker for Alzheimer's disease, Acta Neurologica Scandinavica. Supplementum, 176 pp. 49-52 . ISSN 0065-1427 (2001) [Refereed Article]


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The definitive published version is available online at: http://www3.interscience.wiley.com/

DOI: doi:10.1034/j.1600-0404.2000.00307.x

Abstract

The identification of a biochemical marker of Alzheimer's disease (AD) is a major research aim of many groups. Abnormal levels of tau and Aβ have been identified in the cerebrospinal fluid (CSF) of AD patients, although the sensitivity and specificity of the changes in these two biomarkers alone is not sufficient to be of diagnostic value. Recently, our group has identified an abnormality in the glycosylation of acetylcholinesterase (AChE). The increase in this glycoform of AChE is very specific for Alzheimer's disease and is not seen in many other neurological diseases including other dementias.

Item Details

Item Type:Refereed Article
Keywords: acetylcholinesterase; amyloid; glycosylation; cholinergic; diagnosis; Alzheimer's disease
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Neurosciences not elsewhere classified
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Neurodegenerative Disorders Related to Ageing
Author:Small, DH (Professor David Small)
ID Code:75362
Year Published:2001
Deposited By:Research Division
Deposited On:2012-01-25
Last Modified:2012-02-02
Downloads:0

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