File(s) under permanent embargo
An unusually glycosylated form of acetylcholinesterase is a CSF biomarker for Alzheimer's disease
journal contribution
posted on 2023-05-17, 10:00 authored by Saez-Valero, J, Mok, SS, David SmallDavid SmallThe identification of a biochemical marker of Alzheimer's disease (AD) is a major research aim of many groups. Abnormal levels of tau and Aβ have been identified in the cerebrospinal fluid (CSF) of AD patients, although the sensitivity and specificity of the changes in these two biomarkers alone is not sufficient to be of diagnostic value. Recently, our group has identified an abnormality in the glycosylation of acetylcholinesterase (AChE). The increase in this glycoform of AChE is very specific for Alzheimer's disease and is not seen in many other neurological diseases including other dementias.
History
Publication title
Acta Neurologica Scandinavica. SupplementumVolume
176Pagination
49-52ISSN
0065-1427Department/School
Menzies Institute for Medical ResearchPublisher
Wiley-Blackwell Publishing, Inc.Place of publication
United StatesRights statement
The definitive published version is available online at: http://www3.interscience.wiley.com/Repository Status
- Restricted