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Altered glycosylation of cerebrospinal fluid butyrylcholinesterase in Alzheimer's disease

Citation

Saez-Valero, J and Small, DH, Altered glycosylation of cerebrospinal fluid butyrylcholinesterase in Alzheimer's disease, Brain Research, 889, (1-2) pp. 247-250. ISSN 0006-8993 (2001) [Refereed Article]


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DOI: doi:10.1016/S0006-8993(00)03144-9

Abstract

Our previous studies have shown that a minor isoform of acetylcholinesterase (AChE) is increased in the cerebrospinal fluid (CSF) of Alzheimer’s disease (AD) patients. In the present study, the glycosylation of butyrycholinesterase (BuChE) was found to be altered in AD CSF. By combining an analysis of CSF AChE and BuChE glycosylation, it is possible to identify cases of AD with more than 90% sensitivity and specificity.

Item Details

Item Type:Refereed Article
Keywords: Glycosylation; Acetylcholinesterase; Butyrylcholinesterase; Alzheimer’s disease; Diagnosis; Cerebrospinal fluid
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Neurosciences not elsewhere classified
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Neurodegenerative Disorders Related to Ageing
Author:Small, DH (Professor David Small)
ID Code:75361
Year Published:2001
Web of Science® Times Cited:12
Deposited By:Research Division
Deposited On:2012-01-25
Last Modified:2012-02-02
Downloads:1 View Download Statistics

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