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Pilot clinical study to evaluate the anticoagulant activity of fucoidan

Citation

Irhimeh, MR and Fitton, JH and Lowenthal, RM, Pilot clinical study to evaluate the anticoagulant activity of fucoidan, Blood Coagulation & Fibrinolysis, 20, (7) pp. 607-610. ISSN 0957-5235 (2009) [Refereed Article]


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Copyright Statement

Copyright 2009 Lippincott Williams & Wilkins, Inc.

DOI: doi:10.1097/MBC.0b013e32833135fe

Abstract

Seaweed-derived heparin-like substances such as fucoidan have been extensively studied in vitro as potential blood anticoagulants. However, there have been no human studies investigating the anticoagulant activity of fucoidan when administered orally. This pilot clinical trial was aimed to assess the safety and clinical effects of fucoidan ingestion on hemostasis as well as study its in-vitro anticoagulant activity. In a single-blinded clinical trial, a total of 20 human volunteers were allocated to both the placebo group (n = 10) who ingested 3 g of guar gum capsules and to the active treatment group (n = 10) who ingested 3 g of 75% fucoidan capsules for 12 days. Platelet indices, activated partial thromboplastin time, antithrombin-III, thrombin time, prothrombin time, and antifactor-Xa were analyzed according to standard methods. In vivo, activated partial thromboplastin time increased from 28.41 to 34.01 s (n = 10, P = 0.01), thrombin time decreased from 18.62 to 17.55 s (n = 10, P = 0.04), and antithrombin-III increased from 113.5 to 117% (n = 10, P = 0.03). The in-vitro fucoidan anticoagulant activity was found prominent. It increased activated partial thromboplastin time, thrombin time, and prothrombin time, whereas antithrombin-III decreased. In-vivo effect of fucoidan on hemostasis was not obvious probably due to low intestinal absorption. Thus, fucoidan in the form used in this study does not seem to have an oral anticoagulant activity, but it has a very strong in-vitro anticoagulant activity.

Item Details

Item Type:Refereed Article
Keywords:activated partial thromboplastin time, anticoagulant, fucoidan, hemostasis, polyanions, seaweed, sulfated polysaccharides, Undaria pinnatifida
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Haematology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Blood Disorders
Author:Irhimeh, MR (Dr Mohammad Irhimeh)
Author:Lowenthal, RM (Professor Ray Lowenthal)
ID Code:75314
Year Published:2009
Web of Science® Times Cited:23
Deposited By:Medicine (Discipline)
Deposited On:2012-01-23
Last Modified:2013-02-05
Downloads:2 View Download Statistics

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