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Continuing to wear nicotine patches after smoking lapses promotes recovery of abstinence


Ferguson, SG and Gitchell, JG and Shiffman, S, Continuing to wear nicotine patches after smoking lapses promotes recovery of abstinence, Addiction, 107, (7) pp. 1349-1353. ISSN 1360-0443 (2012) [Refereed Article]

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Copyright Statement

Copyright 2012 Society for the Study of Addiction

DOI: doi:10.1111/j.1360-0443.2012.03801.x


Aims: Smokers who lapse during a cessation attempt are at particularly high risk of relapse, so interventions to help smokers recover from lapses are urgently needed. Two recent studies have suggested continuing to use nicotine patches following a lapse may be a beneficial relapse prevention strategy. However, to date no study that uses approved doses of nicotine patches under real-world conditions has tested this hypothesis. Design & Setting: Clinical trial conducted across eight US study sites. Participants & Measurements: Using data from 509 subjects (240 active; 269 placebo) who lapsed during weeks 3-5 of treatment in a randomized, double blind placebo controlled trial of 21-mg nicotine patches, we examined whether active nicotine patch use improved the chances of recovering abstinence (7-day point-prevalence) at weeks 6 and 10. Findings: Active patch use (versus placebo) increased the likelihood of recovery from a lapse both at 6 weeks (8.3% vs 0.8%; Relative Risk [RR]=11.0, p<.001) and at 10 weeks (9.6% vs 2.6%; RR=3.7, p<.001). Conclusions: Continuing treatment to aid smoking cessation with active patches promotes recovery from lapses. Smokers should be encouraged to persist with patch treatment if they lapse to smoking.

Item Details

Item Type:Refereed Article
Keywords:nicotine replacement therapy, nicotine patch, relapse prevention, smoking cessation
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Clinical pharmacology and therapeutics
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Preventive medicine
UTAS Author:Ferguson, SG (Professor Stuart Ferguson)
ID Code:75088
Year Published:2012
Web of Science® Times Cited:29
Deposited By:Pharmacy
Deposited On:2012-01-09
Last Modified:2017-11-02

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