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Six common ringtail possums (Psewbcheirus peregrinus) were intravenously injected with a standard dose of radioactive 3-Methylhistidine (N’-[Me-‘4C]MeH). The dose was rapidly and quantitatively excreted by the possums. More than 90% of radioactivity was recovered within 3 days. Thin layer chromatography and mass spectroscopy showed that 97% of recovered radioactivity was associated with unmetabolised N’-[Me-14C)MeH. These data satisfy two key requirements for the validity of urinary 3-Methylhistidine (Nr-3MeH) excretion as an index of muscle protein catabolism in P. peregrinus.

Item Type:	Refereed Article
Keywords:	3-Methylhistidine; Nô-[Me-14C]MeH; muscle protein catabolism; common ringtail possum; Pseudocheirus peregrinus; arboreal folivore; marsupial; eucalyptus
Research Division:	Biomedical and Clinical Sciences
Research Group:	Pharmacology and pharmaceutical sciences
Research Field:	Basic pharmacology
Objective Division:	Environmental Management
Objective Group:	Other environmental management
Objective Field:	Other environmental management not elsewhere classified
UTAS Author:	McLean, S (Professor Stuart McLean)
UTAS Author:	Brandon, S (Mrs Susan Brandon)
UTAS Author:	Davies, NW (Associate Professor Noel Davies)
ID Code:	7508
Year Published:	1996
Web of Science® Times Cited:	2
Deposited By:	Pharmacy
Deposited On:	1996-08-01
Last Modified:	2011-08-19
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