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Quantitative urinary excretion of unmetabolised N tau-[Me-C-14]methylhistidine by the common ringtail possum (Pseudocheirus peregrinus) Marsupialia

Citation

Watson, S and Foley, W and McLean, S and Brandon, S and Davies, NW, Quantitative urinary excretion of unmetabolised N tau-[Me-C-14]methylhistidine by the common ringtail possum (Pseudocheirus peregrinus) Marsupialia, Comparative Biochemistry and Physiology. A: Physiology, 115, (1) pp. 53-55. ISSN 0300-9629 (1996) [Refereed Article]

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DOI: doi:10.1016/0300-9629(96)00001-1

Abstract

Six common ringtail possums (Psewbcheirus peregrinus) were intravenously injected with a standard dose of radioactive 3-Methylhistidine (N-[Me-4C]MeH). The dose was rapidly and quantitatively excreted by the possums. More than 90% of radioactivity was recovered within 3 days. Thin layer chromatography and mass spectroscopy showed that 97% of recovered radioactivity was associated with unmetabolised N-[Me-14C)MeH. These data satisfy two key requirements for the validity of urinary 3-Methylhistidine (Nr-3MeH) excretion as an index of muscle protein catabolism in P. peregrinus.

Item Details

Item Type:Refereed Article
Keywords:3-Methylhistidine; N-[Me-14C]MeH; muscle protein catabolism; common ringtail possum; Pseudocheirus peregrinus; arboreal folivore; marsupial; eucalyptus
Research Division:Medical and Health Sciences
Research Group:Pharmacology and Pharmaceutical Sciences
Research Field:Basic Pharmacology
Objective Division:Environment
Objective Group:Flora, Fauna and Biodiversity
Objective Field:Flora, Fauna and Biodiversity of environments not elsewhere classified
Author:McLean, S (Professor Stuart McLean)
Author:Brandon, S (Mrs Susan Brandon)
Author:Davies, NW (Associate Professor Noel Davies)
ID Code:7508
Year Published:1996
Web of Science® Times Cited:2
Deposited By:Pharmacy
Deposited On:1996-08-01
Last Modified:2011-08-19
Downloads:0

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