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Pilot Study of Nebulised Morphine for Dyspnoea in Palliative Care Patients
journal contribution
posted on 2023-05-21, 17:34 authored by Gregory PetersonGregory Peterson, Young, R, Dunne, P, Galloway, G, Parks, TObjective: To investigate the efficacy of nebulised morphine for dyspnoea in a controlled trial involving eight terminally ill patients. Method: Over three consecutive days, patients received treatment for one day with four nebulised doses of either sodium chloride 0.9%, morphine 2.5 mg or morphine 5 mg. Both subjective severity of dyspnoea and respiratory function were monitored with each treatment. Results: Analysis of variance indicated that there was a statistically significant difference in the subjective symptoms of dyspnoea and respiratory function between individual patients. However, there was no evidence of any beneficial effects of nebulised morphine or saline in these patients, who were all receiving regular morphine by either the oral or subcutaneous route. Conclusion: This small trial suggests that there would be limited value in adding nebulised morphine, at the dosage studied, to oral or subcutaneous therapy in palliative care patients with dyspnoea.
History
Publication title
Australian Journal of Hospital PharmacyVolume
26Issue
5Pagination
545-547ISSN
0310-6810Department/School
School of Pharmacy and PharmacologyPublisher
Society of Hospital Pharmacists of AustraliaPlace of publication
AustraliaRights statement
Copyrights 1999 Society of Hospital Pharmacists of AustraliaRepository Status
- Restricted