Health economic consequences of irbesartan treatment of type 2 diabetes patients with nephropathy and hypertension in German
Palmer, AJ and Annemans, L and Roze, S and Lamotte, M and Rodby, RA and Ritz, E, Collaborative Study Group, Health economic consequences of irbesartan treatment of type 2 diabetes patients with nephropathy and hypertension in German, Deutsche Medizinische Wochenschrift, 129, (1-2) pp. 13-18. ISSN 0012-0472 (2004) [Refereed Article]
Background and aims: The "Irbesartan in Diabetic Nephropathy Trial" (IDNT), demonstrated a reduction in the combined endpoint of doubling of serum creatinine, end-stage renal disease (ESRD) or death compared to control or amlodipine arms in patients with hypertension, type 2 diabetes and overt nephropathy when treated with irbesartan. Aim of this study is to compare long-term consequences in costs and outcomes of IDNT treatment alternatives from the German health care system's perspective. Methods: A Markov model simulated progression from overt nephropathy to doubling of serum creatinine, end-stage renal disease, and death in patients with hypertension, type 2 diabetes and overt nephropathy for the three treatment arms. Treatment-specific probabilities were derived from IDNT. German-specific ESRD-related data were retrieved from published sources to reflect local management practices, ESRD outcomes and costs. A time horizon of 10 years was used. Delay in onset of ESRD and mean costs per patient were calculated. Future costs were discounted at 5% per annum. Results: The cumulative incidence of ESRD after 10 years with irbesartan (36%) is lower compared to amlodipine (49%) or control (45%). Irbesartan leads to cost savings of 14424 EUR and 8 720 EUR per patient versus amlodipine or control respectively. Conclusion: Treating patients with hypertension, type 2 diabetes and nephropathy using irbesartan lowers the cumulative incidence of ESRD and is cost-saving compared to amlodipine or control.