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Irbesartan is projected to be cost and life saving in a Spanish setting for treatment of patients with type 2 diabetes, hypertension, and microalbuminuria


Palmer, AJ and Annemans, L and Roze, S and Lapuerta, P and Chen, R and Gabriel, S and Carita, P and Rodby, RA and de Zeeuw, D and Parving, HH and De Alvaro, F, Irbesartan is projected to be cost and life saving in a Spanish setting for treatment of patients with type 2 diabetes, hypertension, and microalbuminuria, Kidney International, 67, (Supplement 93) pp. S52-S54 . ISSN 0085-2538 (2005) [Refereed Article]

DOI: doi:10.1111/j.1523-1755.2005.09312.x


Objectives. The purpose of this study was to project the cumulative incidence of end-stage renal disease (ESRD), life expectancy, and costs in a Spanish setting of treating patients with diabetes, hypertension, and microalbuminuria with either standard hypertension treatment alone or standard hypertension treatment plus irbesartan 300 mg daily. Methods. A peer-reviewed, published Markov model that simulated progression from microalbuminuria to nephropathy, doubling of serum creatinine, ESRD, and all-cause mortality in patients with hypertension, type 2 diabetes, and microalbuminuria was adapted to a Spanish setting. Two strategies were compared: (1) irbesartan versus (2) standard hypertension care with comparable blood pressure control; both began in diabetic hypertensive subjects with microalbuminuria. Cumulative incidence of ESRD, costs, and life expectancy were projected for a hypothetical cohort of 1000 subjects. Future costs and life expectancy were discounted at 3% yearly. A 25-year time horizon and third party payer perspective were used. Results. When compared to standard blood pressure control, irbesartan was projected to reduce the cumulative incidence of ESRD from (mean ± standard deviation) 24 ± 1% to 9 ± 2%, save €11,082 ± 2,996, and add 1.40 ± 0.27 life years per treated patient. The superiority of irbesartan over standard care was robust under a wide range of plausible assumptions. Conclusion. Treating patients with hypertension, microalbuminuria, and type 2 diabetes with irbesartan was projected to reduce the incidence of ESRD, extend life, and reduce costs.

Item Details

Item Type:Refereed Article
Research Division:Economics
Research Group:Applied economics
Research Field:Health economics
Objective Division:Health
Objective Group:Evaluation of health and support services
Objective Field:Evaluation of health and support services not elsewhere classified
UTAS Author:Palmer, AJ (Professor Andrew Palmer)
ID Code:74692
Year Published:2005
Web of Science® Times Cited:18
Deposited By:Research Division
Deposited On:2011-12-12
Last Modified:2011-12-13

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