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Cost-effectiveness of insulin aspart versus human soluble insulin in type 2 diabetes in four European countries: subgroup analyses from the PREDICTIVE study
journal contribution
posted on 2023-05-17, 09:26 authored by Palmer, JL, Goodall, G, Nielsen, S, Kotchie, RW, Valentine, WJ, Andrew PalmerAndrew Palmer, Roze, SObjectives: To evaluate the long-term health economic outcomes associated with insulin aspart (IAsp) compared to human soluble insulin (HI) in type 2 diabetes patients on basal-bolus therapy in Sweden, Spain, Italy and Poland. Methods: A published computer simulation model of diabetes was used to predict life expectancy, quality-adjusted life expectancy and incidence of diabetes-related complications. Baseline cohort characteristics (age 61.6 years, duration of diabetes 13.2 years, 45.1% male, HbA 1c 8.2%, BMI 29.8 kg/m 2) and treatment effects were derived from the PREDICTIVE observational study. Country-specific complication costs were derived from published sources. The analyses were run over 35-year time horizons from third-party payer perspectives in Spain, Italy and Poland and from a societal perspective in Sweden. Future costs and clinical benefits were discounted at country-specific discount rates. Sensitivity analyses were performed. Results: IAsp was associated with improvements in discounted life expectancy and quality-adjusted life expectancy, and a reduced incidence of most diabetes-related complications versus HI in all four settings. IAsp was associated with societal cost-savings in Sweden (SEK 2470), direct medical cost-savings in Sweden and Spain (SEK 8248 and €1382, respectively), but increased direct costs in Italy (€2235) and Poland (€743). IAsp was associated with improved quality-adjusted life expectancy in Sweden (0.077 QALYs), Spain (0.080 QALYs), Italy (0.120 QALYs) and Poland (0.003 QALYs). Conclusions: IAsp was dominant versus HI in both Sweden and Spain, would be considered cost-effective in Italy with an incremental cost-effectiveness ratio of €18 597 per QALY gained, but would not be considered cost-effective in Poland. © 2008 Informa UK Ltd. All rights reserved.
History
Publication title
Current Medical Research and OpinionVolume
24Issue
5Pagination
1417-1428ISSN
0300-7995Department/School
Menzies Institute for Medical ResearchPublisher
LibrapharmPlace of publication
C/O Dr. Peter L Clarke, 26-32 Venture West, New Greenham Park, Newbury, England, Berkshire, Rg19 6HxRepository Status
- Restricted