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Health economic consequences of insulin analogues in the treatment of type 1 diabetes in Denmark


Palmer, AJ and Lammert, M and Hermansen, K, Health economic consequences of insulin analogues in the treatment of type 1 diabetes in Denmark, Ugeskrift for Laeger , 170, (15) pp. 1250-1254. ISSN 1603-6824 (2008) [Refereed Article]


Introduction: Diabetes is a major challenge to the Danish health care system, and complications account for the majority of total treatment costs. Materials and methods: The majority of type 1 diabetes patients in Denmark are treated with the flexible basal-bolus insulin regimen. Use of insulin analogues provides superior metabolic control, lower blood glucose viability, flexible life style, reduced frequency of hypoglycaemia and no undesired weight gain. The long term health economic consequences were projected in a published and validated Markov model. Treatment effects of insulin analogues and a similar human insulin regimen were based on results from a clinical RCT study and Danish health care costs were applied in the model. Results: In the model, the improved glycaemic control and the reduction in hypoglycaemia episodes obtained with insulin analogues resulted in a reduction in late stage diabetes complications, improved quality of life and increased life expectancy compared to human insulin. The incremental costs-effectiveness ratio was estimated to DKK 55,867 per quality-adjusted life year gained, which is considered beneficial to society. Conclusion: Modelling predicts insulin analogues to be a cost-effective alternative to human insulin in Denmark.

Item Details

Item Type:Refereed Article
Research Division:Economics
Research Group:Applied economics
Research Field:Health economics
Objective Division:Health
Objective Group:Evaluation of health and support services
Objective Field:Evaluation of health and support services not elsewhere classified
UTAS Author:Palmer, AJ (Professor Andrew Palmer)
ID Code:74619
Year Published:2008
Deposited By:Research Division
Deposited On:2011-12-08
Last Modified:2011-12-13

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