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Childhood Adiposity, Adult Adiposity, and Cardiovascular Risk Factors

Citation

Juonala, M and Magnussen, CG and Berenson, GS and Venn, A and Burns, TL and Sabin, MA and Srinivasan, SR and Daniels, SR and Davis, PH and Chen, W and Sun, C and Cheung, M and Viikari, JSA and Dwyer, T and Raitakari, OT, Childhood Adiposity, Adult Adiposity, and Cardiovascular Risk Factors, New England Journal of Medicine, 365, (20) pp. 1876-1885. ISSN 0028-4793 (2011) [Refereed Article]


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Copyright Statement

Copyright 2011 Massachusetts Medical Society

DOI: doi:10.1056/NEJMoa1010112

Abstract

Background Obesity in childhood is associated with increased cardiovascular risk. It is uncertain whether this risk is attenuated in persons who are overweight or obese as children but not obese as adults. Methods We analyzed data from four prospective cohort studies that measured childhood and adult body-mass index (BMI, the weight in kilograms divided by the square of the height in meters). The mean length of follow-up was 23 years. To define high adiposity status, international age-specific and sex-specific BMI cutoff points for overweight and obesity were used for children, and a BMI cutoff point of 30 was used for adults. Results Data were available for 6328 subjects. Subjects with consistently high adiposity status from childhood to adulthood, as compared with persons who had a normal BMI as children and were nonobese as adults, had an increased risk of type 2 diabetes (relative risk, 5.4; 95% confidence interval [CI], 3.4 to 8.5), hypertension (relative risk, 2.7; 95% CI, 2.2 to 3.3), elevated low-density lipoprotein cholesterol levels (relative risk, 1.8; 95% CI, 1.4 to 2.3), reduced high-density lipoprotein cholesterol levels (relative risk, 2.1; 95% CI, 1.8 to 2.5), elevated triglyceride levels (relative risk, 3.0; 95% CI, 2.4 to 3.8), and carotid-artery atherosclerosis (increased intima¨Cmedia thickness of the carotid artery) (relative risk, 1.7; 95% CI, 1.4 to 2.2) (P¡Ü0.002 for all comparisons). Persons who were overweight or obese during childhood but were nonobese as adults had risks of the outcomes that were similar to those of persons who had a normal BMI consistently from childhood to adulthood (P>0.20 for all comparisons). Conclusions Overweight or obese children who were obese as adults had increased risks of type 2 diabetes, hypertension, dyslipidemia, and carotid-artery atherosclerosis. The risks of these outcomes among overweight or obese children who became nonobese by adulthood were similar to those among persons who were never obese. (Funded by the Academy of Finland and others.)

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Cardiology (incl. Cardiovascular Diseases)
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cardiovascular System and Diseases
Author:Magnussen, CG (Dr Costan Magnussen)
Author:Venn, A (Professor Alison Venn)
ID Code:74615
Year Published:2011
Web of Science® Times Cited:404
Deposited By:Menzies Institute for Medical Research
Deposited On:2011-12-08
Last Modified:2012-06-18
Downloads:4 View Download Statistics

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