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Measures of Symptoms and Disease Status in Ankylosing Spondylitis


Zochling, J, Measures of Symptoms and Disease Status in Ankylosing Spondylitis, Arthritis Care & Research, 63, (S11) pp. S47-S58. ISSN 2151-464X (2011) [Refereed Article]

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DOI: doi:10.1002/acr.20575


Outcome measurement in spondylarthritis, particularly ankylosing spondylitis (AS) has been a rapidly growing field over the last decade, with enormous progress being made in patient-reported outcomes, clinical assessments, physical measurements and composite scoring of disease state, and response to treatment. Many of these advances arose out of need, when anti–tumor necrosis factor therapies were found to have a role in the treatment of AS patients and therefore required appropriate clinical assessment. The Assessment of SpondyloArthritis international Society (ASAS) was first formed in 1995 as a group of clinicians and methodologists with a shared interest in outcome measurement in AS patients, and has grown to incorporate early diagnosis, classification, development and validation of outcome measures, and evaluation of therapeutic modalities. The instruments reviewed here include those recommended in the ASAS core sets for clinical record keeping (in daily clinical practice) and for clinical research, as over time these have been extensively validated and implemented across different clinical settings. The core sets describe those health-related domains that "should" be measured in AS patients in different settings, and recommend appropriate instruments that can be used for that domain. Additional measures included are the AS Quality of Life scale and the Health Assessment Questionnaire for the Spondylarthropathies, which cover health domains not included in the original core sets but have been shown to be important to AS patients through the World Health Organization International Classification of Functioning, Disability and Health projects (1). Finally, the AS Disease Activity Score has also been presented, as an alternative to the Bath Ankylosing Spondylitis Disease Activity Index, as one of the newest measures constructed to assess disease activity.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Zochling, J (Dr Jane Zochling)
ID Code:74557
Year Published:2011
Web of Science® Times Cited:49
Deposited By:Menzies Institute for Medical Research
Deposited On:2011-12-07
Last Modified:2017-11-02
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