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Excess body fat is associated with higher risk of vertebral deformities in older women but not in men: a cross-sectional study

Citation

Laslett, LL and Just, SJ and Quinn, SJ and Winzenberg, TM and Jones, G, Excess body fat is associated with higher risk of vertebral deformities in older women but not in men: a cross-sectional study, Osteoporosis International, 23, (1) pp. 67-74. ISSN 1433-2965 (2012) [Refereed Article]

Copyright Statement

Copyright 2011 International Osteoporosis Foundation and National Osteoporosis Foundation

DOI: doi:10.1007/s00198-011-1741-8

Abstract

Summary: Thinness is a risk factor for fractures, but the effect of obesity on fracture risk is less clear. We found an association between measures of obesity and prevalence and number of vertebral deformities in women but not in men, in a cross-sectional study of 1,011 participants aged 50-80 years.

Introduction: Low body weight is well recognised as a risk factor for fractures, but the association between overweight and fracture risk is less well described. This cross-sectional study describes the association between measures of obesity and vertebral deformities in 1,011 male and female participants in the Tasmanian Older Adult Cohort study.

Methods: Vertebral deformities (anterior wedging) of T4-CL4 were determined by morphometric dual-emission X-ray absorptiometry. Body fat was assessed as weight, body mass index (BMI), waist-hip ratio (WHR), waist circumference and DXA measures of trunk fat (in percent) and total fat mass.

Results: The mean age of participants was 637 years, and mean BMI was 285. Prevalent thoracic vertebral deformities were associated with increasing weight [standardised β (Sβ) 0.29, p=0.003], BMI (Sβ 0.33, p<0.001), trunk fat (Sβ 0.20, p=0.03), waist circumference (Sβ 0.19, p=0.03) and fat mass (Sβ 0.23, p=0.03), but not the WHR in women, and only with decreasing total fat mass in men. In addition, the number of vertebral deformities increased as weight, BMI or fat mass increased in women (all p<0.05) but decreased with increasing total fat mass in men. Associations between fat mass and vertebral deformities were mainly linear, but there was some evidence of a threshold effect in women with a BMI ≥35.

Conclusions: There is a deleterious association between increasing amounts of body fat in women but not in men and the prevalence and number of vertebral deformities, which may reflect loading of the thoracic spine.

Item Details

Item Type:Refereed Article
Keywords:obesity, osteoporosis/epidemiology, risk factors, vertebral deformity, vertebral fracture
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Laslett, LL (Dr Laura Laslett)
Author:Just, SJ (Ms Stella Foley)
Author:Winzenberg, TM (Professor Tania Winzenberg)
Author:Jones, G (Professor Graeme Jones)
ID Code:74540
Year Published:2012 (online first 2011)
Web of Science® Times Cited:27
Deposited By:Menzies Institute for Medical Research
Deposited On:2011-12-07
Last Modified:2017-11-02
Downloads:0

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