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The association between oral contraceptive use, bone mineral density and fractures in women aged 50-80 years


Wei, S and Venn, A and Ding, C and Foley, S and Laslett, L and Jones, G, The association between oral contraceptive use, bone mineral density and fractures in women aged 50-80 years, Contraception, 84, (4) pp. 357-362. ISSN 0010-7824 (2011) [Refereed Article]

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DOI: doi:10.1016/j.contraception.2011.02.001


BACKGROUND: The associations between oral contraceptive (OC) use, bone mineral density (BMD) and the risk of fractures remain controversial. STUDY DESIGN: A cross-sectional study of 491 women aged 50-80 years was performed. We assessed OC use and fractures by questionnaire, and BMD and vertebral deformity by dual-energy x-ray absorptiometry. RESULTS: Ever use of OC was associated with significantly higher BMD at the total body (6%, p<.001) and spine (4%; p=.05) (but not hip) after adjustment for confounders. There was also a significant association between duration of OC use and total body and spine BMD. Use of OCs for 5-10 years was associated with reduced vertebral deformity (adjusted odds ratio 0.46, 95% confidence interval 0.22-0.94). CONCLUSIONS: Oral contraceptive use and duration were associated with higher total body and spine BMD and a consistent reduction in vertebral deformities, although most associations did not reach significance.

Item Details

Item Type:Refereed Article
Keywords:Oral contraceptive; Bone mineral density; Vertebral deformity; Fracture; Population
Research Division:Health Sciences
Research Group:Epidemiology
Research Field:Epidemiology not elsewhere classified
Objective Division:Health
Objective Group:Specific population health (excl. Indigenous health)
Objective Field:Women's and maternal health
UTAS Author:Wei, S (Mrs Shuying Wei)
UTAS Author:Venn, A (Professor Alison Venn)
UTAS Author:Ding, C (Professor Chang-Hai Ding)
UTAS Author:Foley, S (Ms Stella Foley)
UTAS Author:Laslett, L (Dr Laura Laslett)
UTAS Author:Jones, G (Professor Graeme Jones)
ID Code:74330
Year Published:2011
Web of Science® Times Cited:10
Deposited By:Menzies Institute for Medical Research
Deposited On:2011-11-22
Last Modified:2012-03-29

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