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UV-induced immunosuppression and the efficacy of vaccination
Citation
Norval, M and Woods, GM, UV-induced immunosuppression and the efficacy of vaccination, Photochemical & Photobiological Sciences, 10, (8) pp. 1267-1274. (2011) [Review Several Works]
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Abstract
Exposure to ultraviolet radiation (UVR) suppresses immunity by complex pathways, initiated by
chromophores located in the skin and ending with the generation of specific subsets of T and B
regulatory cells. The primary and memory (recall) immune response to a wide variety of antigens,
including microorganisms, can be reduced by UVR, leading to the possibility that the efficacy of
vaccination could be similarly reduced. A limited number of animal models of vaccination demonstrate
that this may indeed be the case. The situation in human subjects has not been rigorously assessed but
there are indications from a variety of sources that UVR adversely affects the immune responses to
several vaccines. These studies are reviewed and the implications for vaccine administration discussed.
As vaccination represents a major public health measure world-wide for the control of an increasing
number of common infections, it is important to maximise its efficacy; therefore further evaluation of
UVR in the context of vaccination is required and warranted.
Item Details
Item Type: | Review Several Works |
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Research Division: | Biomedical and Clinical Sciences |
Research Group: | Immunology |
Research Field: | Cellular immunology |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Woods, GM (Professor Gregory Woods) |
ID Code: | 74253 |
Year Published: | 2011 |
Web of Science® Times Cited: | 22 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2011-11-16 |
Last Modified: | 2011-11-16 |
Downloads: | 1 View Download Statistics |
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