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UV-induced immunosuppression and the efficacy of vaccination

Citation

Norval, M and Woods, GM, UV-induced immunosuppression and the efficacy of vaccination, Photochemical & Photobiological Sciences, 10, (8) pp. 1267-1274. (2011) [Review Several Works]

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DOI: doi:10.1039/c1pp05105a

Abstract

Exposure to ultraviolet radiation (UVR) suppresses immunity by complex pathways, initiated by chromophores located in the skin and ending with the generation of specific subsets of T and B regulatory cells. The primary and memory (recall) immune response to a wide variety of antigens, including microorganisms, can be reduced by UVR, leading to the possibility that the efficacy of vaccination could be similarly reduced. A limited number of animal models of vaccination demonstrate that this may indeed be the case. The situation in human subjects has not been rigorously assessed but there are indications from a variety of sources that UVR adversely affects the immune responses to several vaccines. These studies are reviewed and the implications for vaccine administration discussed. As vaccination represents a major public health measure world-wide for the control of an increasing number of common infections, it is important to maximise its efficacy; therefore further evaluation of UVR in the context of vaccination is required and warranted.

Item Details

Item Type:Review Several Works
Research Division:Medical and Health Sciences
Research Group:Immunology
Research Field:Cellular Immunology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Immune System and Allergy
Author:Woods, GM (Professor Gregory Woods)
ID Code:74253
Year Published:2011
Web of Science® Times Cited:15
Deposited By:Menzies Institute for Medical Research
Deposited On:2011-11-16
Last Modified:2011-11-16
Downloads:1 View Download Statistics

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