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The associations between parity, other reproductive factors and cartilage in women aged 50-80 years

Citation

Wei, S and Venn, A and Ding, C and Martel-Pelletier, J and Pelletier, J-P and Abram, F and Cicuttini, F and Jones, G, The associations between parity, other reproductive factors and cartilage in women aged 50-80 years, Osteoarthritis and Cartilage: Journal of The Osteoarthritis Research Society International, 19, (11) pp. 1307-1313. ISSN 1063-4584 (2011) [Refereed Article]

Copyright Statement

Copyright 2011 Osteoarthritis Research Society International

DOI: doi:10.1016/j.joca.2011.07.020

Abstract

Objective: Sex hormones and reproductive factors may be important for osteoarthritis (OA). The aim of this study was to describe the associations of parity, use of hormone replacement therapy (HRT) and oral contraceptives (OCs) with cartilage volume, cartilage defects and radiographic OA in a population-based sample of older women. Design: Cross-sectional study of 489 women aged 50-80 years. Parity, use of HRT and OC was assessed by questionnaire; knee cartilage volume and defects by magnetic resonance imaging and knee joint space narrowing (JSN) and osteophytes by X-ray. Results: Parity was associated with a deficit in total knee cartilage volume [adjusted = 0.69 ml, 95% confidence interval (CI) 1.34, 0.04]. Increasing parity was associated with decreasing cartilage volume in both the tibial compartment and total knee (both P trend <0.05). Parity was also associated with greater cartilage defects in the patella compartment [adjusted odds ratio (OR) = 2.87, 95% CI = 1.39, 5.93] but not other sites. There was a consistent but non-significant increase in knee JSN (OR = 2.78, 95% CI = 0.75, 10.31) and osteophytes (OR = 1.69, 95% CI = 0.59, 4.82) for parous women. Use of HRT and/or OC was not associated with cartilage volume, cartilage defects or radiographic change. Conclusions: Parity (but not use of HRT or OC) is independently associated with lower cartilage volume primarily in the tibial compartment and higher cartilage defects in the patella compartment in this population-based sample of older women.

Item Details

Item Type:Refereed Article
Keywords:Parity, Cartilage volume, Cartilage defects, Osteoarthritis, Population
Research Division:Medical and Health Sciences
Research Group:Public Health and Health Services
Research Field:Epidemiology
Objective Division:Health
Objective Group:Specific Population Health (excl. Indigenous Health)
Objective Field:Women's Health
Author:Wei, S (Mrs Shuying Wei)
Author:Venn, A (Professor Alison Venn)
Author:Ding, C (Professor Chang-Hai Ding)
Author:Jones, G (Professor Graeme Jones)
ID Code:74207
Year Published:2011
Web of Science® Times Cited:9
Deposited By:Menzies Institute for Medical Research
Deposited On:2011-11-15
Last Modified:2017-11-02
Downloads:0

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