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Relationship between antioxidant enzyme genotype and activity and kidney function: a case-control study


Crawford, A and Fassett, RG and Coombes, JS and Kunde, DA and Ahuja, KDK and Robertson, IK and Ball, MJ and Geraghty, DP, Relationship between antioxidant enzyme genotype and activity and kidney function: a case-control study, Clinical Nephrology, 78, (2) pp. 135-144. ISSN 0301-0430 (2012) [Refereed Article]

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Copyright Statement

Copyright 2012 Dustri-Verlag

DOI: doi:10.5414/CN107421


Background: Oxidative stress is associated with the progression of chronic kidney disease (CKD). Links between antioxidant enzyme SNPs such as superoxide dismutase (SOD) Ala16Val, glutathione peroxidase (GPx) Pro197Leu and catalase C-262T and CKD have not been investigated. This study compared antioxidant genotypes and activities of CKD patients with population controls, and determined their relationship to kidney function. Methods: CKD patients (n=230) and controls (n=224) were screened for the GPx, SOD and catalase SNPs. Plasma and red blood cell (RBC) GPx, RBC SOD and RBC catalase activities, and estimated glomerular filtration rate (eGFR) were measured. Results: Significantly more CKD patients (n=5) had the GPx Leu/Leu genotype compared to controls (n=0), and had lower eGFR (p=0.054). CKD patients had significantly lower plasma GPx and RBC catalase activities compared to controls, whereas RBC GPx and RBC SOD activities were significantly higher in CKD patients (p<0.001). Conclusions: CKD is associated with reduced plasma GPx and catalase activities and enhanced RBC GPx and SOD activities. Although, genotype frequencies were similar for both groups, lower eGFR was associated with the GPx Leu/Leu genotype.

Item Details

Item Type:Refereed Article
Keywords:Single nucleotide polymorphisms; antioxidant enzymes; glomerular filtration rate; chronic kidney disease progression
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Nephrology and urology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Crawford, A (Miss Amanda Crawford)
UTAS Author:Kunde, DA (Dr Dale Kunde)
UTAS Author:Ahuja, KDK (Dr Kiran Ahuja)
UTAS Author:Robertson, IK (Dr Iain Robertson)
UTAS Author:Ball, MJ (Professor Madeleine Ball)
UTAS Author:Geraghty, DP (Professor Dominic Geraghty)
ID Code:74020
Year Published:2012
Web of Science® Times Cited:15
Deposited By:Health Sciences A
Deposited On:2011-11-08
Last Modified:2013-05-01
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