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PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice

journal contribution
posted on 2023-05-17, 08:36 authored by Rivers, LE, Kaylene YoungKaylene Young, Rizzi, M, Jamen, F, Psachoulia, K, Wade, A, Kessaris, N, Richardson, WD
Platelet-derived growth factor α receptor (PDGFRA)/NG2-expressing glia are distributed throughout the adult CNS. They are descended from oligodendrocyte precursors (OLPs) in the perinatal CNS, but it is not clear whether they continue to generate myelinating oligodendrocytes or other differentiated cells during normal adult life. We followed the fates of adult OLPs in Pdgfra-creERT2/Rosa26-YFP double-transgenic mice and found that they generated many myelinating oligodendrocytes during adulthood; >20% of all oligodendrocytes in the adult mouse corpus callosum were generated after 7 weeks of age, raising questions about the function of the late-myelinating axons. OLPs also produced some myelinating cells in the cortex, but the majority of adult-born cortical cells did not appear to myelinate. We found no evidence for astrocyte production in gray or white matter. However, small numbers of projection neurons were generated in the forebrain, especially in the piriform cortex, which is the main target of the olfactory bulb. © 2008 Nature Publishing Group.

History

Publication title

Nature Neuroscience

Volume

11

Issue

12

Pagination

1392-1401

ISSN

1097-6256

Department/School

Menzies Institute for Medical Research

Publisher

Nature Publishing Group

Place of publication

345 Park Ave South, New York, USA, Ny, 10010-1707

Repository Status

  • Restricted

Socio-economic Objectives

Expanding knowledge in the biological sciences

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