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PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice


Rivers, LE and Young, KM and Rizzi, M and Jamen, F and Psachoulia, K and Wade, A and Kessaris, N and Richardson, WD, PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice, Nature Neuroscience, 11, (12) pp. 1392-1401. ISSN 1097-6256 (2008) [Refereed Article]

DOI: doi:10.1038/nn.2220


Platelet-derived growth factor α receptor (PDGFRA)/NG2-expressing glia are distributed throughout the adult CNS. They are descended from oligodendrocyte precursors (OLPs) in the perinatal CNS, but it is not clear whether they continue to generate myelinating oligodendrocytes or other differentiated cells during normal adult life. We followed the fates of adult OLPs in Pdgfra-creERT2/Rosa26-YFP double-transgenic mice and found that they generated many myelinating oligodendrocytes during adulthood; >20% of all oligodendrocytes in the adult mouse corpus callosum were generated after 7 weeks of age, raising questions about the function of the late-myelinating axons. OLPs also produced some myelinating cells in the cortex, but the majority of adult-born cortical cells did not appear to myelinate. We found no evidence for astrocyte production in gray or white matter. However, small numbers of projection neurons were generated in the forebrain, especially in the piriform cortex, which is the main target of the olfactory bulb. © 2008 Nature Publishing Group.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Cellular nervous system
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the biological sciences
UTAS Author:Young, KM (Professor Kaylene Young)
ID Code:73674
Year Published:2008
Web of Science® Times Cited:646
Deposited By:Research Division
Deposited On:2011-10-21
Last Modified:2011-10-21

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