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CNS-Resident Glial Progenitor/Stem Cells Produce Schwann Cells as well as Oligodendrocytes during Repair of CNS Demyelination

Citation

Zawadzka, M and Rivers, LE and Fancy, SPJ and Zhao, C and Tripathi, R and Jamen, F and Young, KM and Goncharevich, A and Pohl, H and Rizzi, M and Rowitch, DH and Kessaris, N and Suter, U and Richardson, WD and Franklin, RJM, CNS-Resident Glial Progenitor/Stem Cells Produce Schwann Cells as well as Oligodendrocytes during Repair of CNS Demyelination, Cell Stem Cell , 6, (6) pp. 578-590. ISSN 1934-5909 (2010) [Refereed Article]

DOI: doi:10.1016/j.stem.2010.04.002

Abstract

After central nervous system (CNS) demyelination - such as occurs during multiple sclerosis - there is often spontaneous regeneration of myelin sheaths, mainly by oligodendrocytes but also by Schwann cells. The origins of the remyelinating cells have not previously been established. We have used Cre-lox fate mapping in transgenic mice to show that PDGFRA/NG2-expressing glia, a distributed population of stem/progenitor cells in the adult CNS, produce the remyelinating oligodendrocytes and almost all of the Schwann cells in chemically induced demyelinated lesions. In contrast, the great majority of reactive astrocytes in the vicinity of the lesions are derived from preexisting FGFR3-expressing cells, likely to be astrocytes. These data resolve a long-running debate about the origins of the main players in CNS remyelination and reveal a surprising capacity of CNS precursors to generate Schwann cells, which normally develop from the embryonic neural crest and are restricted to the peripheral nervous system. © 2010 Elsevier Inc.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Cellular Nervous System
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Biological Sciences
Author:Young, KM (Dr Kaylene Young)
ID Code:73671
Year Published:2010
Web of Science® Times Cited:218
Deposited By:Research Division
Deposited On:2011-10-21
Last Modified:2011-10-21
Downloads:0

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