eCite Digital Repository

Structural Basis for Hemoglobin Capture by Staphylococcus aureus Cell-surface Protein, IsdH

Citation

Kumar, KK and Jacques, DA and Pishchany, G and Caradoc-Davies, T and Spirig, T and Malmirchegini, GR and Langley, DB and Dickson, CF and Mackay, JP and Clubb, RT and Skaar, EP and Guss, JM and Gell, DA, Structural Basis for Hemoglobin Capture by Staphylococcus aureus Cell-surface Protein, IsdH, Journal of Biological Chemistry, 286, (44) pp. 38439-38447. ISSN 0021-9258 (2011) [Refereed Article]


Preview
PDF
Restricted - Request a copy
3Mb
  

Copyright Statement

Copyright 2011 The American Society for Biochemistry and Molecular Biology, Inc.

DOI: doi:10.1074/jbc.M111.287300

Abstract

Background: Bacteria need iron from the host to establish infection. Results: We report the first structure of hemoglobin bound to a bacterial protein and show that targeted disruption of this interaction can reduce Staphylococcus aureus growth when hemoglobin is the sole iron source. Conclusion: Physical capture of hemoglobin is important for iron uptake by S. aureus. Significance: Hemoglobin receptors may be targets for new antibacterial agents.

Item Details

Item Type:Refereed Article
Research Division:Biological Sciences
Research Group:Biochemistry and Cell Biology
Research Field:Structural Biology (incl. Macromolecular Modelling)
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Infectious Diseases
Author:Dickson, CF (Miss Claire Dickson)
Author:Gell, DA (Dr David Gell)
ID Code:73632
Year Published:2011
Web of Science® Times Cited:33
Deposited By:Menzies Institute for Medical Research
Deposited On:2011-10-19
Last Modified:2012-06-26
Downloads:0

Repository Staff Only: item control page