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Modulation of lymphocyte migration to the murine spleen after macrophage phagocytosis of blood-borne particulate material
journal contribution
posted on 2023-05-17, 08:34 authored by Alan Lyons, Watkins, M, Simpson, CC, Muller, HKOur previous studies identified a role for MZM in the movement of lymphocytes into the splenic white pulp. Here we show that phagocytosis of colloidal carbon by marginal zone macrophages results in a splenic influx of B lymphocytes, and T lymphocytes of memory/activated phenotype, with concomitant upregulation of B Lymphocyte Chemoattractant (BLC, CXCL13) mRNA, a chemokine acting on B and memory/activated T lymphocytes. The recruitment of B cells and activated T cells to the spleen after phagocytic uptake would allow an immune response against blood-borne pathogens to be quickly and effectively mounted by bringing together the two key cell types responsible for generating humoral immunity
History
Publication title
Immunological Investigations: A Journal of Molecular and Cellular ImmunologyVolume
35Pagination
75-92ISSN
0882-0139Department/School
Tasmanian School of MedicinePublisher
Marcel Dekker IncPlace of publication
270 Madison Ave, New York, USA, Ny, 10016Repository Status
- Restricted