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Modulation of lymphocyte migration to the murine spleen after macrophage phagocytosis of blood-borne particulate material

Citation

Lyons, AB and Watkins, M and Simpson, CC and Muller, HK, Modulation of lymphocyte migration to the murine spleen after macrophage phagocytosis of blood-borne particulate material, Immunological Investigations: A Journal of Molecular and Cellular Immunology, 35, (1) pp. 75-92. ISSN 0882-0139 (2006) [Refereed Article]

DOI: doi:10.1080/08820130500496811

Abstract

Our previous studies identified a role for MZM in the movement of lymphocytes into the splenic white pulp. Here we show that phagocytosis of colloidal carbon by marginal zone macrophages results in a splenic influx of B lymphocytes, and T lymphocytes of memory/activated phenotype, with concomitant upregulation of B Lymphocyte Chemoattractant (BLC, CXCL13) mRNA, a chemokine acting on B and memory/activated T lymphocytes. The recruitment of B cells and activated T cells to the spleen after phagocytic uptake would allow an immune response against blood-borne pathogens to be quickly and effectively mounted by bringing together the two key cell types responsible for generating humoral immunity

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Immunology
Research Field:Cellular Immunology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Immune System and Allergy
Author:Lyons, AB (Dr Bruce Lyons)
Author:Muller, HK (Professor Konrad Muller)
ID Code:73624
Year Published:2006
Web of Science® Times Cited:1
Deposited By:Medicine (Discipline)
Deposited On:2011-10-19
Last Modified:2011-10-19
Downloads:0

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