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Modulation of lymphocyte migration to the murine spleen after macrophage phagocytosis of blood-borne particulate material
Citation
Lyons, AB and Watkins, M and Simpson, CC and Muller, HK, Modulation of lymphocyte migration to the murine spleen after macrophage phagocytosis of blood-borne particulate material, Immunological Investigations: A Journal of Molecular and Cellular Immunology, 35, (1) pp. 75-92. ISSN 0882-0139 (2006) [Refereed Article]
DOI: doi:10.1080/08820130500496811
Abstract
Our previous studies identified a role for MZM in the movement of lymphocytes into the splenic white pulp. Here we show that phagocytosis of colloidal carbon by marginal zone macrophages results in a splenic influx of B lymphocytes, and T lymphocytes of memory/activated phenotype, with concomitant upregulation of B Lymphocyte Chemoattractant (BLC, CXCL13) mRNA, a chemokine acting on B and memory/activated T lymphocytes. The recruitment of B cells and activated T cells to the spleen after phagocytic uptake would allow an immune response against blood-borne pathogens to be quickly and effectively mounted by bringing together the two key cell types responsible for generating humoral immunity
Item Details
| Item Type: | Refereed Article |
|---|---|
| Research Division: | Medical and Health Sciences |
| Research Group: | Immunology |
| Research Field: | Cellular Immunology |
| Objective Division: | Health |
| Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
| Objective Field: | Immune System and Allergy |
| UTAS Author: | Lyons, AB (Associate Professor Bruce Lyons) |
| UTAS Author: | Muller, HK (Professor Konrad Muller) |
| ID Code: | 73624 |
| Year Published: | 2006 |
| Web of Science® Times Cited: | 3 |
| Deposited By: | Medicine |
| Deposited On: | 2011-10-19 |
| Last Modified: | 2011-10-19 |
| Downloads: | 0 |
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