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Model selection and Bayesian methods in statistical genetics: summary of group 11 contributions to Genetic Analysis Workshop 15

Citation

Swartz, MD and Thomas, DC and Daw, EW and Group-11, Model selection and Bayesian methods in statistical genetics: summary of group 11 contributions to Genetic Analysis Workshop 15, Genetic Epidemiology, 31, (Supplement 1) pp. S96-S102. ISSN 0741-0395 (2007) [Refereed Article]


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Copyright Statement

Copyright 2007 Wiley-Liss, Inc. The definitive published version is available online at: http://onlinelibrary.wiley.com/

DOI: doi:10.1002/gepi.20285

Abstract

The research presented in group 11 of the Genetic Analysis Workshop 15 (GAW15) falls into two major themes: Model selection approaches for gene mapping (both Bayesian and Frequentist); and other Bayesian methods. These methods either allow relaxation of some of the common assumptions, such as mode of inheritance, for studying complicated genetic systems, or allow incorporation of additional information into the model. Over half of the groups applied model selection methods on all three data sets, using models in which genetic markers were used as predictors for linkage, phenotype expression, or transmission to an affected offspring. Most groups employed variations of Stochastic Search Variable Selection as the model selection method of choice. A brief review of this class of methods is given in this summary paper, followed by highlights of other methods and overall summaries of each contribution to the GAW15 presentation group 11. These group contributions exhibit the value of framing genetic problems in terms of model selection, and highlight the impact of variable selection for gene mapping.

Item Details

Item Type:Refereed Article
Keywords:complex disease analysis;association study;linkage;heritability;eQTL;SNPs
Research Division:Mathematical Sciences
Research Group:Statistics
Research Field:Biostatistics
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Biological Sciences
Author:Group-11 (Dr Jac Charlesworth)
ID Code:73591
Year Published:2007
Web of Science® Times Cited:4
Deposited By:Research Division
Deposited On:2011-10-18
Last Modified:2012-02-17
Downloads:2 View Download Statistics

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