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Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes
Citation
Goring, HHH and Curran, JE and Johnson, MP and Dyer, TD and Charlesworth, JC and Cole, SA and Jowett, JBM and Abraham, LJ and Rainwater, DL and Comuzzie, AG and Mahaney, MC and Almasy, L and MacCluer, JW and Kissebah, AH and Collier, GR and Moses, EK and Blangero, J, Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes, Nature Genetics, 39, (10) pp. 1208-1216. ISSN 1061-4036 (2007) [Refereed Article]
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Copyright Statement
Copyright © 2007 Nature Publishing Group
Official URL: http://dx.doi.org/10.1038/ng2119
DOI: doi:10.1038/ng2119
Abstract
Quantitative differences in gene expression are thought to contribute to phenotypic differences between individuals. We generated genome-wide transcriptional profiles of lymphocyte samples from 1,240 participants in the San Antonio Family Heart Study. The expression levels of 85% of the 19,648 detected autosomal transcripts were significantly heritable. Linkage analysis uncovered > 1,000 cis-regulated transcripts at a false discovery rate of 5% and showed that the expression quantitative trait loci with the most significant linkage evidence are often located at the structural locus of a given transcript. To highlight the usefulness of this much- enlarged map of cis-regulated transcripts for the discovery of genes that influence complex traits in humans, as an example we selected high-density lipoprotein cholesterol concentration as a phenotype of clinical importance, and identified the cis-regulated vanin 1 (VNN1) gene as harboring sequence variants that influence high-density lipoprotein cholesterol concentrations.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Research Division: | Biological Sciences |
| Research Group: | Genetics |
| Research Field: | Genomics |
| Objective Division: | Expanding Knowledge |
| Objective Group: | Expanding Knowledge |
| Objective Field: | Expanding Knowledge in the Biological Sciences |
| Author: | Charlesworth, JC (Dr Jac Charlesworth) |
| ID Code: | 73580 |
| Year Published: | 2007 |
| Web of Science® Times Cited: | 361 |
| Deposited By: | Research Division |
| Deposited On: | 2011-10-17 |
| Last Modified: | 2011-11-16 |
| Downloads: | 4 View Download Statistics |
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