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Genetic association of preeclampsia to the inflammatory response gene SEPS1


Moses, EK and Johnson, MP and Tommerdal, L and Forsmo, S and Curran, JE and Abraham, LJ and Charlesworth, JC and Brennecke, SP and Blangero, J and Austgulen, R, Genetic association of preeclampsia to the inflammatory response gene SEPS1 , American Journal of Obstetrics and Gynecology, 198, (3) pp. 336.e1-336.e5. ISSN 0002-9378 (2008) [Refereed Article]

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Copyright 2008 Mosby. The definitive version is available at

DOI: doi:10.1016/j.ajog.2007.09.024


OBJECTIVE: The objective of the study was to test for a genetic association between the G-105A promoter polymorphism of the inflammatory mediator Selenoprotein S (SEPS1) and preeclampsia. STUDY DESIGN: A retrospective study in a large Norwegian case-control cohort compared maternal genotype and allele frequencies of the SEPS1 g.-105G>A polymorphism genotyped by SNPlex assay in preeclamptic (n=1139) and control (n=2269) women. Statistical significance was determined by chi(2) and multivariate regression analyses. RESULTS: Women with preeclampsia were 1.34 times more likely to have the GA or AA genotype (P=.0039; 95% confidence interval [CI] 1.09 to 1.64) and 1.22 times more likely to carry the A allele (P=.023; odds ratio, 1.22; 95% CI, 1.02 to 1.46). CONCLUSION: The A allele of the SEPS1-105G>A polymorphism is a significant risk factor for preeclampsia in this population.

Item Details

Item Type:Refereed Article
Keywords:genetic association, inflammation, polymorphism, preeclampsia, SEPS1
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Gene mapping
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Charlesworth, JC (Dr Jac Charlesworth)
ID Code:73576
Year Published:2008
Web of Science® Times Cited:48
Deposited By:Research Division
Deposited On:2011-10-17
Last Modified:2011-11-17

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