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Isolation and properties of metronidazole-resistant mutants of bacteroides-fragilis


Britz, ML and Wilkinson, RG, Isolation and properties of metronidazole-resistant mutants of bacteroides-fragilis, Antimicrobial Agents and Chemotherapy, 16, (1) pp. 19-27. ISSN 0066-4804 (1979) [Refereed Article]

DOI: doi:10.1128/AAC.16.1.19


Metronidazole-resistant mutants of B. fragilis, isolated after mutagenesis, had diminished ability to take up and metabolize the drug. All the metronidazole-resistant strains had depressed levels of pyruvate dehydrogenase compared with parent cultures. Their end products of glucose metabolism also differed from normal B. fragilis products and were consistent with deficiencies in pyruvate dehydrogenase activity.

Item Details

Item Type:Refereed Article
Research Division:Biological Sciences
Research Group:Microbiology
Research Field:Bacteriology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Infectious Diseases
Author:Britz, ML (Professor Margaret Britz)
ID Code:73230
Year Published:1979
Web of Science® Times Cited:62
Deposited By:Research Division
Deposited On:2011-09-22
Last Modified:2011-09-22

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