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Isolation and properties of metronidazole-resistant mutants of bacteroides-fragilis
journal contribution
posted on 2023-05-17, 08:19 authored by Margaret BritzMargaret Britz, Wilkinson, RGMetronidazole-resistant mutants of B. fragilis, isolated after mutagenesis, had diminished ability to take up and metabolize the drug. All the metronidazole-resistant strains had depressed levels of pyruvate dehydrogenase compared with parent cultures. Their end products of glucose metabolism also differed from normal B. fragilis products and were consistent with deficiencies in pyruvate dehydrogenase activity.
History
Publication title
Antimicrobial Agents and ChemotherapyVolume
16Pagination
19-27ISSN
0066-4804Department/School
College Office - College of Sciences and EngineeringPublisher
Amer Soc MicrobiologyPlace of publication
1752 N St Nw, Washington, USA, Dc, 20036-2904Repository Status
- Restricted