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Childhood Environmental and Genetic Predictors of Adulthood Obesity: The Cardiovascular Risk in Young Finns Study

Citation

Juonala, M and Juhola, J and Magnussen, CG and Wurtz, P and Viikari, JSA and Thomson, R and Seppala, I and Hernesniemi, J and Kahonen, M and Lehtimaki, T and Hurme, M and Telama, R and Mikkila, V and Eklund, C and Rasanen, L and Hintsanen, M and Keltikangas-Jarvinen, L and Kivimaki, M and Raitakari, OT, Childhood Environmental and Genetic Predictors of Adulthood Obesity: The Cardiovascular Risk in Young Finns Study, Journal of Clinical Endocrinology and Metabolism, 96, (9) pp. E1542-E1549. ISSN 0021-972X (2011) [Refereed Article]


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Copyright Statement

Copyright 2011 by The Endocrine Society

DOI: doi:10.1210/jc.2011-1243

Abstract

Context: Obesity from childhood to adulthood is associated with adverse health later in life. Increased youth BMI is a risk factor for later obesity, but it is unknown whether identification of other risk factors, including recently discovered genetic markers, would help to identify children at risk of developing adult obesity. Objectives: Our objective was to examine the childhood environmental and genetic predictors of adult obesity. Design, Setting, and Participants:Wefollowed 2119 individuals of the Cardiovascular Risk inYoung Finns Study for up to 27 yr since baseline (1980, age 3–18 yr). Main Outcome Measure: We evaluated adult obesity [body mass index (BMI) 30 kg/m2]. Results: The independent predictors (P  0.05) of adult obesity included childhood BMI, C-reactive protein (CRP), family income (inverse), mother’s BMI, and polymorphisms near genes TFAP2B, LRRN6C, andFLJ35579.AriskassessmentbasedonchildhoodBMI,mother’sBMI,andfamilyincomewassuperior in predicting obesity compared with the approach using data only on BMI (C-statistics 0.751 vs. 0.772, P0.0015). InclusionofdataonchildhoodCRPandnovelgeneticvariants forBMIdidnotincrementally improve C-value (0.779, P0.16).Anonlaboratory risk score (childhood BMI, mother’s BMI, and family income) predicted adult obesity in all age groups between 3–18 yr (P always 0.001). Conclusions: Childhood BMI, CRP, family income (inversely), mother’s BMI, and polymorphisms near genes FLJ35779, TFAP2B, and LRRN6C are independently related to adulthood obesity. However, because genetic risk markers and CRP only marginally improve the prediction, our results indicate that children at high risk of adult obesity can be identified using a simple non-laboratorybased risk assessment.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Cardiology (incl. Cardiovascular Diseases)
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Diabetes
Author:Magnussen, CG (Dr Costan Magnussen)
Author:Thomson, R (Dr Russell Thomson)
ID Code:73211
Year Published:2011
Web of Science® Times Cited:37
Deposited By:Menzies Institute for Medical Research
Deposited On:2011-09-21
Last Modified:2012-07-05
Downloads:0

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