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Age-related differences in corticospinal excitability during a Go/NoGo task


Fujiyama, H and Tandonnet, C and Summers, JJ, Age-related differences in corticospinal excitability during a Go/NoGo task, Psychophysiology, 48, (10) pp. 1448-1455. ISSN 0048-5772 (2011) [Refereed Article]

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Copyright Statement

Copyright © 2011 Society for Psychophysiological Research The definitive published version is available online at:

DOI: doi:10.1111/j.1469-8986.2011.01201.x


Age-related slowing of reaction times (RTs) is well documented but whether the phenomenon reflects deficits in movement preparation and/or response generation processes is unclear. To gain further insight into this issue, transcranial magnetic stimulation (TMS) was used to investigate motor cortex (M1) excitability and short-interval intracortical inhibitory (SICI) processes during a Go/NoGo RTtask in younger and older adults. Single- and paired-pulse TMS was delivered over the left M1 during preparation and response generation periods in a right-hand muscle. Younger adults had shorter RTs and a larger increase in corticospinal excitability at response generation period than older adults. SICI modulation for both groups showed a large reduction in inhibition immediately prior to EMGonset. These findings indicate age-related differences in corticospinal excitability during the response generation stage of sensorimotor information processing.

Item Details

Item Type:Refereed Article
Keywords:Aging, Go/NoGo reaction time, Corticospinal excitability, Intracortical inhibition, Transcranial magnetic
Research Division:Psychology
Research Group:Cognitive and computational psychology
Research Field:Sensory processes, perception and performance
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in psychology
UTAS Author:Fujiyama, H (Dr Hakuei Fujiyama)
UTAS Author:Tandonnet, C (Dr Christophe Tandonnet)
UTAS Author:Summers, JJ (Professor Jeffery Summers)
ID Code:73165
Year Published:2011
Web of Science® Times Cited:25
Deposited By:Psychology
Deposited On:2011-09-16
Last Modified:2014-12-05

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