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Basement membrane remodelling in COPD responds to inhaled corticosteroids


Soltani, A and Sohal, SS and Reid, D and Weston, S and Muller, HK and Wood-Baker, R and Walters, EH, Basement membrane remodelling in COPD responds to inhaled corticosteroids, The Thoracic Society of Australia & New Zealand Annual Scientific Meeting, April, Brisbane, Australia (2010) [Conference Extract]


Introduction Our knowledge about the effects of inhaled corticosteroids (ICS) on airway remodelling in chronic obstructive pulmonary disease (COPD) is limited. We have previously reported that in bronchial biopsies (BB) from COPD subjects the reticular basement membrane (Rbm) is fragmented and hypervascular. In this study we have examined the effects of ICS on these airway remodelling changes in COPD. Methods In a double blind and randomised study we compared the effects of 6 months of fluticasone propionate (FP, 0.5 mg/twice daily) with placebo. BB were stained with collagen IV antibody to mark vessel endothelial basement membrane. The length of Rbm splits and the number and area of vessels in the Rbm were compared before and after treatment. Results COPD subjects were randomized 2 : 1 to receive either FP (n = 15) or placebo (n = 7). There were no differences between the groups before treatment. The length of Rbm splitting, as an index of Rbm fragmentation, was significantly decreased by FP [median (range) 19.1 (0.242.8) before vs. 2.6 (088.6) lm/lm Rbm 100 after, p < 0.03] but not by placebo [24 (6.6109) before vs. 26.9 (2.548.5) lm/lm Rbm 100 after, p = 0.7]. The number and area of vessels within the Rbm did not change following either FP or placebo. Conclusion We have proposed that Rbm fragmentation is the result of local proteinase activity involved in active epithelial- mesenchymal transition (EMT). The results are likely to represent a suppression of this process by ICS, but this needs confirmation by further investigation of specific EMT markers.

Item Details

Item Type:Conference Extract
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Respiratory diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Soltani, A (Dr Amir Soltani Abhari)
UTAS Author:Sohal, SS (Dr Sukhwinder Sohal)
UTAS Author:Reid, D (Dr David Reid)
UTAS Author:Weston, S (Mr Steven Weston)
UTAS Author:Muller, HK (Professor Konrad Muller)
UTAS Author:Wood-Baker, R (Professor Richard Wood-Baker)
UTAS Author:Walters, EH (Professor Haydn Walters)
ID Code:73125
Year Published:2010
Deposited By:Menzies Institute for Medical Research
Deposited On:2011-09-14
Last Modified:2011-09-14

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