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Microfluidic Chips for Capillary Electrophoresis with Integrated Electrodes for Capacitively Coupled Conductivity Detection based on Printed Circuit Board Technology


Guijt, RM and Armstrong, JP and Candish, E and Lefleur, V and Percey, WJ and Shabala, S and Hauser, PC and Breadmore, MC, Microfluidic Chips for Capillary Electrophoresis with Integrated Electrodes for Capacitively Coupled Conductivity Detection based on Printed Circuit Board Technology, Sensors and Actuators - B: Chemical: International Journal Devoted to Research and Development of Physical and Chemical Transducers, 159, (1) pp. 307-313. ISSN 0925-4005 (2011) [Refereed Article]

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DOI: doi:10.1016/j.snb.2011.06.023


A simple and low budget microfabrication method compatible with mass production was developed for the integration of electrodes for capacitively coupled contactless conductivity detection (C4D) in Lab on a Chip devices. Electrodes were patterned on a printed circuit board using standard processing. This was followed by lamination-photolithography-lamination to cover the electrodes in dry film photoresist (DFR) using an office laminator. This resulted in a flush, smooth surface on top of the detection electrodes, enabling subsequent integration of a microfluidic network at a distance dictated by the thickness of the DFR (17 um, 30 um and 60 um were used in this work). This process was applied to create two types of detectors, re-usable detectors to be used in combination with a separate microfluidic network and integrated detectors where the microfluidic network is irreversibly sealed to the detector. A poly(dimethylsiloxane) (PDMS) slab containing the microfluidic network was positioned on top of the re-usable detectors to create the PDMS hybrid devices. The integrated DFR devices were created by patterning and sealing the microchannel in DFR using subsequent lamination and lithographic steps. The sensitivity of the C4D made using this new technology for small inorganic cations was between 6 and 20 uM, which is comparable with devices made using significantly more advanced technologies. Where the 17 um film slightly improved the sensitivity, the use of 30 um thick insulating films was preferred as these did not impose significant restrictions on the applicable field strengths.

Item Details

Item Type:Refereed Article
Keywords:Microfluidic, Lab on a chip, Capacitively coupled contactless conductivity detection (C4D)
Research Division:Chemical Sciences
Research Group:Analytical chemistry
Research Field:Separation science
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the chemical sciences
UTAS Author:Guijt, RM (Dr Rosanne Guijt)
UTAS Author:Candish, E (Ms Esme Candish)
UTAS Author:Lefleur, V (Ms Veronica Lefleur)
UTAS Author:Percey, WJ (Mr William Percey)
UTAS Author:Shabala, S (Professor Sergey Shabala)
UTAS Author:Breadmore, MC (Professor Michael Breadmore)
ID Code:73068
Year Published:2011
Web of Science® Times Cited:46
Deposited By:Pharmacy
Deposited On:2011-09-09
Last Modified:2022-08-25
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