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Microfluidic Chips for Capillary Electrophoresis with Integrated Electrodes for Capacitively Coupled Conductivity Detection based on Printed Circuit Board Technology

Citation

Guijt, RM and Armstrong, JP and Candish, E and Lefleur, V and Percey, WJ and Shabala, S and Hauser, PC and Breadmore, MC, Microfluidic Chips for Capillary Electrophoresis with Integrated Electrodes for Capacitively Coupled Conductivity Detection based on Printed Circuit Board Technology, Sensors and Actuators - B: Chemical: International Journal Devoted to Research and Development of Physical and Chemical Transducers, 159, (1) pp. 307-313. ISSN 0925-4005 (2011) [Refereed Article]


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Copyright Statement

Copyright © 2011 The definitive version is available at http://www.sciencedirect.com

Official URL: http://www.sciencedirect.com

DOI: doi:10.1016/j.snb.2011.06.023

Abstract

A simple and low budget microfabrication method compatible with mass production was developed for the integration of electrodes for capacitively coupled contactless conductivity detection (C4D) in Lab on a Chip devices. Electrodes were patterned on a printed circuit board using standard processing. This was followed by lamination–photolithography–lamination to cover the electrodes in dry film photoresist (DFR) using an office laminator. This resulted in a flush, smooth surface on top of the detection electrodes, enabling subsequent integration of a microfluidic network at a distance dictated by the thickness of the DFR (17 m, 30 m and 60 m were used in this work). This process was applied to create two types of detectors, re-usable detectors to be used in combination with a separate microfluidic network and integrated detectors where the microfluidic network is irreversibly sealed to the detector. A poly(dimethylsiloxane) (PDMS) slab containing the microfluidic network was positioned on top of the re-usable detectors to create the PDMS hybrid devices. The integrated DFR devices were created by patterning and sealing the microchannel in DFR using subsequent lamination and lithographic steps. The sensitivity of the C4D made using this new technology for small inorganic cations was between 6 and 20 M, which is comparable with devices made using significantly more advanced technologies. Where the 17 m film slightly improved the sensitivity, the use of 30 m thick insulating films was preferred as these did not impose significant restrictions on the applicable field strengths.

Item Details

Item Type:Refereed Article
Keywords:Microfluidic, Lab on a chip, Capacitively coupled contactless conductivity detection (C4D)
Research Division:Chemical Sciences
Research Group:Analytical Chemistry
Research Field:Separation Science
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Chemical Sciences
Author:Guijt, RM (Dr Rosanne Guijt)
Author:Candish, E (Ms Esme Candish)
Author:Lefleur, V (Ms Veronica Lefleur)
Author:Percey, WJ (Mr William Percey)
Author:Shabala, S (Professor Sergey Shabala)
Author:Breadmore, MC (Professor Michael Breadmore)
ID Code:73068
Year Published:2011
Web of Science® Times Cited:32
Deposited By:Pharmacy
Deposited On:2011-09-09
Last Modified:2017-08-25
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