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The nutriceutical bovine colostrum truncates the increase in gut permeability caused by heavy exercise in athletes

Citation

Marchbank, T and Davison, G and Oakes, JR and Ghatei, MA and Patterson, M and Moyer, MP and Playford, RJ, The nutriceutical bovine colostrum truncates the increase in gut permeability caused by heavy exercise in athletes, American Journal of Physiology: Gastrointestinal and Liver Physiology, 300, (3) pp. G477-G484. ISSN 0193-1857 (2011) [Refereed Article]

DOI: doi:10.1152/ajpgi.00281.2010

Abstract

Heavy exercise causes gut symptoms and, in extreme cases, "heat stroke" partially due to increased intestinal permeability of luminal toxins. We examined bovine colostrum, a natural source of growth factors, as a potential moderator of such effects. Twelve volunteers completed a double-blind, placebo-controlled, crossover protocol (14 days colostrum/placebo) prior to standardized exercise. Gut permeability utilized 5 h urinary lactulose-to-rhamnose ratios. In vitro studies (T84, HT29, NCM460 human colon cell lines) examined colostrum effects on temperature-induced apoptosis (active caspase-3 and 9, Baxα, Bcl-2), heat shock protein 70 (HSP70) expression and epithelial electrical resistance. In both study arms, exercise increased blood lactate, heart rate, core temperature (mean 1.4C rise) by similar amounts. Gut hormone profiles were similar in both arms although GLP-1 levels rose following exercise in the placebo but not the colostrum arm (P = 0.026). Intestinal permeability in the placebo arm increased 2.5-fold following exercise (0.38 0.012 baseline, to 0.92 0.014, P < 0.01), whereas colostrum truncated rise by 80% (0.38 0.012 baseline to 0.49 0.017) following exercise. In vitro apoptosis increased by 4765% in response to increasing temperature by 2C. This effect was truncated by 60% if colostrum was present (all P < 0.01). Similar results were obtained examining epithelial resistance (colostrum truncated temperature-induced fall in resistance by 64%, P < 0.01). Colostrum increased HSP70 expression at both 37 and 39C (P < 0.001) and was truncated by addition of an EGF receptor-neutralizing antibody. Temperature-induced increase in Baxα and reduction in Bcl-2 was partially reversed by presence of colostrum. Colostrum may have value in enhancing athletic performance and preventing heat stroke.

Item Details

Item Type:Refereed Article
Keywords:repair, gut growth, injury, clinical trial, Apoptosis Regulatory Proteins, athletes, bovine, colostrum, gastrointestinal hormones, heat stroke, HSP70 heat-shock proteins, intestinal absorption, lactic acid, permeability, physical exertion
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Gastroenterology and Hepatology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Digestive System Disorders
Author:Playford, RJ (Professor Ray Playford)
ID Code:72990
Year Published:2011
Web of Science® Times Cited:39
Deposited By:Faculty of Health
Deposited On:2011-09-05
Last Modified:2012-08-27
Downloads:0

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