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A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21
Citation
van Heel, DA and Franke, L and Hunt, KA and Gwilliam, R and Zhernakova, A and Inouye, M and Wapenaar, MC and Barnardo, MCNM and Bethel, G and Holmes, GKT and Feighery, C and Jewell, D and Kelleher, D and Kumar, P and Travis, S and Walters, JRF and Sanders, DS and Howdle, P and Swift, J and Playford, RJ and McLaren, WM and Mearin, ML and Mulder, C J and McManus, R and McGinnis, R and Cardon, LR and Deloukas, P and Wijmenga, C, A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21, Nature Genetics, 39, (7) pp. 827-829. ISSN 1061-4036 (2007) [Refereed Article]
DOI: doi:10.1038/ng2058
Abstract
We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding (rs13119723; P = 2.0 × 10-7) was in the KIAA1109-TENR-IL2-IL21 linkage disequilibrium block. We independently confirmed association in two further collections (strongest association at rs6822844, 24 kb 5′ of IL21; meta-analysis P = 1.3 × 10-14, odds ratio = 0.63), suggesting that genetic variation in this region predisposes to celiac disease. © 2007 Nature Publishing Group.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Clinical sciences |
| Research Field: | Medical genetics (excl. cancer genetics) |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Clinical health not elsewhere classified |
| UTAS Author: | Playford, RJ (Professor Ray Playford) |
| ID Code: | 72976 |
| Year Published: | 2007 |
| Web of Science® Times Cited: | 496 |
| Deposited By: | Research Division |
| Deposited On: | 2011-09-05 |
| Last Modified: | 2011-09-05 |
| Downloads: | 0 |
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