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A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21

Citation

van Heel, DA and Franke, L and Hunt, KA and Gwilliam, R and Zhernakova, A and Inouye, M and Wapenaar, MC and Barnardo, MCNM and Bethel, G and Holmes, GKT and Feighery, C and Jewell, D and Kelleher, D and Kumar, P and Travis, S and Walters, JRF and Sanders, DS and Howdle, P and Swift, J and Playford, RJ and McLaren, WM and Mearin, ML and Mulder, C J and McManus, R and McGinnis, R and Cardon, LR and Deloukas, P and Wijmenga, C, A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21, Nature Genetics, 39, (7) pp. 827-829. ISSN 1061-4036 (2007) [Refereed Article]

DOI: doi:10.1038/ng2058

Abstract

We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding (rs13119723; P = 2.0 × 10-7) was in the KIAA1109-TENR-IL2-IL21 linkage disequilibrium block. We independently confirmed association in two further collections (strongest association at rs6822844, 24 kb 5′ of IL21; meta-analysis P = 1.3 × 10-14, odds ratio = 0.63), suggesting that genetic variation in this region predisposes to celiac disease. © 2007 Nature Publishing Group.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Medical Genetics (excl. Cancer Genetics)
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Digestive System Disorders
Author:Playford, RJ (Professor Ray Playford)
ID Code:72976
Year Published:2007
Web of Science® Times Cited:418
Deposited By:Research Division
Deposited On:2011-09-05
Last Modified:2011-09-05
Downloads:0

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