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Bone marrow-derived stromal cells express lineage-related messenger RNA species


Direkze, NC and Jeffery, R and Hodivala-Dilke, K and Hunt, T and Playford, RJ and Elia, G and Poulsom, R and Wright, NA and Alison, MR, Bone marrow-derived stromal cells express lineage-related messenger RNA species, Cancer Research, 66, (3) pp. 1265-1269. ISSN 0008-5472 (2006) [Refereed Article]

DOI: doi:10.1158/0008-5472.CAN-05-3202


Evidence has emerged that bone marrow cells have a greater degree of plasticity than previously thought. However, there has been a call to establish proof that these bone marrow-derived cells function appropriately in their new environment. We have already shown that the bone marrow contributes to myofibroblasts in multiple organs and that this is exacerbated by injury and occurs in a mouse tumor model. Here, we provide evidence that these cells are functioning appropriately by showing that bone marrow-derived myofibroblasts are expressing mRNA for the α1 chain of type I (pro)collagen using a new customized technique. This provides evidence that the bone marrow-tumor stroma axis is functionally relevant and may therefore subsequently be exploited to develop new strategies for anticancer therapy. ©2006 American Association for Cancer Research.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Gastroenterology and hepatology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Playford, RJ (Professor Ray Playford)
ID Code:72952
Year Published:2006
Web of Science® Times Cited:41
Deposited By:Research Division
Deposited On:2011-09-05
Last Modified:2011-09-05

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