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Bone marrow-derived stromal cells express lineage-related messenger RNA species

journal contribution
posted on 2023-05-17, 08:08 authored by Direkze, NC, Jeffery, R, Hodivala-Dilke, K, Hunt, T, Playford, RJ, Elia, G, Poulsom, R, Wright, NA, Alison, MR
Evidence has emerged that bone marrow cells have a greater degree of plasticity than previously thought. However, there has been a call to establish proof that these bone marrow-derived cells function appropriately in their new environment. We have already shown that the bone marrow contributes to myofibroblasts in multiple organs and that this is exacerbated by injury and occurs in a mouse tumor model. Here, we provide evidence that these cells are functioning appropriately by showing that bone marrow-derived myofibroblasts are expressing mRNA for the α1 chain of type I (pro)collagen using a new customized technique. This provides evidence that the bone marrow-tumor stroma axis is functionally relevant and may therefore subsequently be exploited to develop new strategies for anticancer therapy. ©2006 American Association for Cancer Research.

History

Publication title

Cancer Research

Volume

66

Pagination

1265-1269

ISSN

0008-5472

Department/School

College Office - College of Health and Medicine

Publisher

Amer Assoc Cancer Research

Place of publication

615 Chestnut St, 17Th Floor, Philadelphia, USA, Pa, 19106-4404

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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