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Accelerated exposure of phosphatidylserine on lymphocyte populations from patients with systemic lupus erythematosus or rheumatoid arthritis

Citation

Albrecht, C and Soumian, S and Playford, RJ and Higgins, CF and Vyse, T and Elliott, JI, Accelerated exposure of phosphatidylserine on lymphocyte populations from patients with systemic lupus erythematosus or rheumatoid arthritis, Thrombosis and Haemostasis, 93, (5) pp. 989-992. ISSN 0340-6245 (2005) [Refereed Article]

Abstract

To summarise, we have shown that lymphocyte populations from patients with SLE, RA and, to a lesser extent, IBD, exhibit an increased rate of calcium ionophore-stimulated exposure of PS to the cell surface, as evidenced by the increased proportion of responding cells. It is not possible from these experiments, however, to assess whether the rate at which PS is translocated from the inner leaflet on individual cells differs between patients and controls. The cause(s) of the increased rates of PS exposure we have observed remain to be elucidated. Indeed, little is known about the mechanism of PS translocation. Whilst it has been suggested that the protein ABCA1 acts as a PS floppase and rates of PS translocation are reduced in haematopoietic cells from ABCA1-deficient mice (14), as there is no evidence for direct interaction between ABCA1 and PS this protein may act upstream of any translocase. We did not find any significant difference in the level of leukocyte ABCA1 mRNA between patients and controls (not shown). These findings indicate that increased rates of exposure of PS in SLE, RA and IBD may contribute toward the elevated thrombotic risk in each disorder. © 2005 Schattauer GmbH, Stuttgart.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Gastroenterology and Hepatology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Digestive System Disorders
Author:Playford, RJ (Professor Ray Playford)
ID Code:72941
Year Published:2005
Web of Science® Times Cited:1
Deposited By:Research Division
Deposited On:2011-09-05
Last Modified:2011-09-05
Downloads:0

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