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Development of a two-site ELISA assay for the dimeric form of human TFF1

Citation

Pu, M and May, FEB and Playford, RJ and Ruchaud-Sparagano, MH and Westley, BR, Development of a two-site ELISA assay for the dimeric form of human TFF1, Peptides: An International Journal, 25, (5) pp. 731-736. ISSN 0196-9781 (2004) [Refereed Article]

DOI: doi:10.1016/j.peptides.2004.01.014

Abstract

TFF1 is one of three human trefoil proteins expressed principally in the gastrointestinal tract in normal tissues. TFF1 protects the gastric mucosa against damage as a result of its ability to facilitate reconstitution of damaged gastric mucosa and its involvement in the secretion and structure of gastric mucus. The most biologically active molecular form in cell culture and animal models tested is a dimer formed by a disulfide bond between two cysteine residues close to the C terminus of the protein. We have therefore developed an assay for this form of TFF1 which should facilitate its measurement in biological samples. © 2004 Elsevier Inc. All rights reserved.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Gastroenterology and Hepatology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Digestive System Disorders
Author:Playford, RJ (Professor Ray Playford)
ID Code:72923
Year Published:2004
Web of Science® Times Cited:3
Deposited By:Research Division
Deposited On:2011-09-05
Last Modified:2011-09-05
Downloads:0

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