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Development of a two-site ELISA assay for the dimeric form of human TFF1
journal contribution
posted on 2023-05-17, 08:07 authored by Pu, M, May, FEB, Playford, RJ, Ruchaud-Sparagano, MH, Westley, BRTFF1 is one of three human trefoil proteins expressed principally in the gastrointestinal tract in normal tissues. TFF1 protects the gastric mucosa against damage as a result of its ability to facilitate reconstitution of damaged gastric mucosa and its involvement in the secretion and structure of gastric mucus. The most biologically active molecular form in cell culture and animal models tested is a dimer formed by a disulfide bond between two cysteine residues close to the C terminus of the protein. We have therefore developed an assay for this form of TFF1 which should facilitate its measurement in biological samples. © 2004 Elsevier Inc. All rights reserved.
History
Publication title
Peptides: An International JournalVolume
25Issue
5Pagination
731-736ISSN
0196-9781Department/School
College Office - College of Health and MedicinePublisher
Elsevier Science IncPlace of publication
360 Park Ave South, New York, USA, Ny, 10010-1710Repository Status
- Restricted