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Human pancreatic secretory trypsin inhibitor : distribution, actions and possible role in mucosal integrity and repair

Citation

Marchbank, T and Freeman, TC and Playford, RJ, Human pancreatic secretory trypsin inhibitor : distribution, actions and possible role in mucosal integrity and repair, Digestion: International Journal of Gastroenterology, 59, (3) pp. 167-174. ISSN 0012-2823 (1998) [Refereed Article]

DOI: doi:10.1159/000007485

Abstract

Pancreatic secretory trypsin inhibitor is a potent protease inhibitor which was originally identified in the pancreas. It has subsequently been shown to be present in mucus-secreting cells throughout the gastrointestinal tract and also in the kidney, lung and breast. Its major roles are likely to be to prevent premature activation of pancreatic proteases and to decrease the rate of mucus digestion by luminal proteases within the stomach and colon. In addition, PSTI increases the proliferation of a variety of cell lines and stimulates cell migration, possibly acting via the EGF receptor. These findings suggest that PSTI may also be involved in both the early and late phases of the healing response following injury. Further studies including the production of transgenic overexpression and knockout models should help elucidate the physiological function of this peptide.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Gastroenterology and Hepatology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Digestive System Disorders
Author:Playford, RJ (Professor Ray Playford)
ID Code:72863
Year Published:1998
Web of Science® Times Cited:43
Deposited By:Research Division
Deposited On:2011-09-02
Last Modified:2011-09-05
Downloads:0

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