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pH-dependent secretion of gastrin in duodenal ulcer disease: effect of suppressing Helicobacter pylori

Citation

Moss, SF and Playford, RJ and Ayesu, K and Li, SK and Calam, J, pH-dependent secretion of gastrin in duodenal ulcer disease: effect of suppressing Helicobacter pylori, Digestion: International Journal of Gastroenterology, 52, (3-4) pp. 173-178. ISSN 0012-2823 (1992) [Refereed Article]

DOI: doi:10.1159/000200950

Abstract

Patients with duodenal ulcers and Helicobacter pylori infection have elevated plasma gastrin concentrations which fall after suppression of the organism. This may be due to H. pylori elevating the pH of the antral mucous layer, therefore preventing luminal acid from inhibiting gastrin release. To test this idea, we measured the plasma gastrin concentrations under basal conditions and in response to 4% peptone when the gastric lumen was maintained at pH 2.5 and at pH 5.5 by gastric perfusion. We studied 11 duodenal ulcer patients before and after suppression of H. pylori. Gastrin concentrations were significantly higher before suppression of H. pylori than after treatment in all three states; basal gastrin (pmol/l) fell from 9.2 (3.7-23, median and range) to 5.1 (1.7-15) after treatment; from 11.3 (3.8-29) to 5.9 (5.7-6.1) at pH 2.5 and from 15.2 (3.9-32) to 7.15 (6.1-14) at pH 5.5. The ratio of peptone-stimulated gastrin at pH2.5/pH5.5 was similar before (0.8; 0.5-1.7) and after (0.8; 0.5-1.1) suppression of H. pylori. These results indicate that infection with H. pylori increases basal and peptone-stimulated plasma gastrin concentrations, and that this response is independent of luminal pH. © 1992 S. Karger AG, Basel.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Gastroenterology and Hepatology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Digestive System Disorders
Author:Playford, RJ (Professor Ray Playford)
ID Code:72828
Year Published:1992
Web of Science® Times Cited:10
Deposited By:Research Division
Deposited On:2011-09-01
Last Modified:2011-09-05
Downloads:0

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