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Suppression of Helicobacter pylori reduces gastrin releasing peptide stimulated gastrin release in duodenal ulcer patients

journal contribution
posted on 2023-05-17, 08:04 authored by Beardshall, K, Moss, S, Gill, J, Levi, S, Ghosh, P, Playford, RJ, Calam, J
Helicobacter pylori increases gastrin release in duodenal ulcer patients. This may be through disruption or changes in the mucus layer affecting the access of luminal stimulants to gastrin releasing cells. The effect of suppressing H pylori on gastrin release stimulated by a non-luminal stimulus, gastrin releasing peptide (GRP), was examined. Eleven patients with active duodenal ulcer disease and colonised with H pylori received an intravenous infusion of GRP (2.9 pmol/kg/minute for 30 minutes) and the plasma gastrin response was measured. Basal and peak pentagastrin stimulated acid output were also determined. Patients were treated with tripotassium dicitratobismuthate (De-Nol) and metronidazole to suppress H pylori and the tests were repeated. Suppression of H pylori decreased plasma gastrin concentrations during GRP infusion, but acid output was not affected. Chromatographic analysis of the forms of gastrin in plasma showed a significant fall in gastrin 17, the predominant form found in the gastric antrum. Gastrin 34 did not fall significantly. This study shows that suppression of H pylori decreases the hypergastrinaemia caused by the non-luminal stimulant, GRP, mainly via decreasing gastrin 17.

History

Publication title

Gut: An International Journal of Gastroenterology and Hepatology

Volume

33

Issue

5

Pagination

601-603

ISSN

0017-5749

Department/School

College Office - College of Health and Medicine

Publisher

B M J Publishing Group

Place of publication

British Med Assoc House, Tavistock Square, London, England, Wc1H 9Jr

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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