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Hypergastrinaemia: a new mechanism
Citation
Deprez, PH and Ghosh, P and Goodlad, RA and Lacey, SL and Millership, S and Playford, RJ and Lee, CY and Calam, J, Hypergastrinaemia: a new mechanism, The Lancet, 338, (8764) pp. 410-411 . ISSN 0140-6736 (1991) [Refereed Article]
DOI: doi:10.1016/0140-6736(91)91034-R
Abstract
The mechanism by which lack of gastric acid causes hypergastrinaemia was investigated in seven patients with pernicious anaemia. Perfusion of gastric juice from the fasting patients (adjusted to pH 7·0) into the stomachs of conscious rats caused a significant rise in plasma gastrin (median 14 [range 2-20] pmol/l to 27 [12-65] pmol/l; p<0·01), whereas perfusion of bicarbonate buffer (18 [13-23] pmol/l to 20 [9-25] pmol/l) or gastric juice from a duodenal ulcer patient (also pH 7·0; 13 [3-30] pmol/l to 17 [9-27] pmol/l) had no significant effect. During gastric lavage at pH 7·0 the median plasma gastrin concentration of the pernicious anaemia patients fell from 320 (63-1760) pmol/l to 125 (46-760) pmol/l (p<0·03). © 1991.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Clinical sciences |
| Research Field: | Gastroenterology and hepatology |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Clinical health not elsewhere classified |
| UTAS Author: | Playford, RJ (Professor Ray Playford) |
| ID Code: | 72801 |
| Year Published: | 1991 |
| Web of Science® Times Cited: | 9 |
| Deposited By: | Research Division |
| Deposited On: | 2011-08-31 |
| Last Modified: | 2011-09-05 |
| Downloads: | 0 |
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