eCite Digital Repository

Hypergastrinaemia: a new mechanism


Deprez, PH and Ghosh, P and Goodlad, RA and Lacey, SL and Millership, S and Playford, RJ and Lee, CY and Calam, J, Hypergastrinaemia: a new mechanism, The Lancet, 338, (8764) pp. 410-411 . ISSN 0140-6736 (1991) [Refereed Article]

DOI: doi:10.1016/0140-6736(91)91034-R


The mechanism by which lack of gastric acid causes hypergastrinaemia was investigated in seven patients with pernicious anaemia. Perfusion of gastric juice from the fasting patients (adjusted to pH 7·0) into the stomachs of conscious rats caused a significant rise in plasma gastrin (median 14 [range 2-20] pmol/l to 27 [12-65] pmol/l; p<0·01), whereas perfusion of bicarbonate buffer (18 [13-23] pmol/l to 20 [9-25] pmol/l) or gastric juice from a duodenal ulcer patient (also pH 7·0; 13 [3-30] pmol/l to 17 [9-27] pmol/l) had no significant effect. During gastric lavage at pH 7·0 the median plasma gastrin concentration of the pernicious anaemia patients fell from 320 (63-1760) pmol/l to 125 (46-760) pmol/l (p<0·03). © 1991.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Gastroenterology and hepatology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Playford, RJ (Professor Ray Playford)
ID Code:72801
Year Published:1991
Web of Science® Times Cited:9
Deposited By:Research Division
Deposited On:2011-08-31
Last Modified:2011-09-05

Repository Staff Only: item control page