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Preliminary report: role of peptide YY in defence against diarrhoea
journal contribution
posted on 2023-05-17, 08:03 authored by Playford, RJ, Domin, J, Beacham, J, Parmar, KB, Tatemoto, K, Bloom, SR, Calam, JTo investigate whether peptide YY (PYY) has a role in minimising fluid loss during diarrhoea, its effect on hypersecretion induced by vasoactive intestinal peptide (VIP) was studied in seven subjects with ileostomies. An isotonic electrolyte solution containing polyethylene glycol 4000 was infused directly into the duodenum and the effluent was collected for 40 min (baseline), then VIP was infused intravenously at 5 pmol.kg-1.min-1 for 500 min. PYY was infused intravenously at low doses (0·4 and 0·2 pmol.kg-1.min-1) for 100 min each during the continuous VIP infusion. Small-intestinal secretion was assessed by effluent weight and by polyethylene glycol dilution, which gave similar results. Plateau ileal output was 501 (SEM 33) ml/h during VIP infusion. PYY caused significant falls in secretion-to 404 (48) ml/h for the lower dose and to 323 (75) ml/h for the higher. It also prolonged small-bowel transit. These findings suggest that PYY is a natural inhibitor of diarrhoea and that its therapeutic potential merits investigation. © 1990.
History
Publication title
The LancetVolume
335Issue
8705Pagination
1555-1557ISSN
0140-6736Department/School
College Office - College of Health and MedicinePublisher
Lancet LtdPlace of publication
84 Theobalds Rd, London, England, Wc1X 8RrRepository Status
- Restricted