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Biosignificance of bacterial cyanogenesis in the CF lung


Anderson, R and Roddam, LF and Bettiol, SS and Sanderson, Kevin and Reid, DW, Biosignificance of bacterial cyanogenesis in the CF lung, Journal of Cystic Fibrosis, 9, (3) pp. 158-164. ISSN 1569-1993 (2010) [Refereed Article]

DOI: doi:10.1016/j.jcf.2009.12.003


Two recent studies have demonstrated the presence of biologically significant amounts of cyanide within the airways of cystic fibrosis (CF) patients infected with Pseudomonas aeruginosa. Whilst environmental strains of P. aeruginosa are known to synthesise cyanide, there has been a relative lack of investigation into bacterial cyanogenesis from a medical viewpoint, despite the role P. aeruginosa plays in many serious infection settings and especially in CF lung disease. This review discusses the implications of cyanogenesis in the CF airway in terms of bacterial ecology, host immune response, progression of lung disease and potential treatment options

Item Details

Item Type:Refereed Article
Research Division:Biological Sciences
Research Group:Microbiology
Research Field:Infectious agents
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Anderson, R (Mr Robert Anderson)
UTAS Author:Roddam, LF (Dr Louise Roddam)
UTAS Author:Bettiol, SS (Dr Silvana Bettiol)
UTAS Author:Sanderson, Kevin (Dr Kevin Sanderson)
UTAS Author:Reid, DW (Dr David Reid)
ID Code:72689
Year Published:2010
Web of Science® Times Cited:26
Deposited By:Medicine
Deposited On:2011-08-30
Last Modified:2015-02-05

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