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Biosignificance of bacterial cyanogenesis in the CF lung

journal contribution
posted on 2023-05-17, 07:54 authored by Anderson, R, Louise RoddamLouise Roddam, Silvana BettiolSilvana Bettiol, Sanderson, Kevin, Reid, DW
Two recent studies have demonstrated the presence of biologically significant amounts of cyanide within the airways of cystic fibrosis (CF) patients infected with Pseudomonas aeruginosa. Whilst environmental strains of P. aeruginosa are known to synthesise cyanide, there has been a relative lack of investigation into bacterial cyanogenesis from a medical viewpoint, despite the role P. aeruginosa plays in many serious infection settings and especially in CF lung disease. This review discusses the implications of cyanogenesis in the CF airway in terms of bacterial ecology, host immune response, progression of lung disease and potential treatment options

History

Publication title

Journal of Cystic Fibrosis

Volume

9

Pagination

158-164

ISSN

1569-1993

Department/School

Tasmanian School of Medicine

Publisher

Elsevier Science

Place of publication

Amsterdam

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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