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Biosignificance of bacterial cyanogenesis in the CF lung
journal contribution
posted on 2023-05-17, 07:54 authored by Anderson, R, Louise RoddamLouise Roddam, Silvana BettiolSilvana Bettiol, Sanderson, Kevin, Reid, DWTwo recent studies have demonstrated the presence of biologically significant amounts of cyanide within the airways of cystic fibrosis (CF) patients infected with Pseudomonas aeruginosa. Whilst environmental strains of P. aeruginosa are known to synthesise cyanide, there has been a relative lack of investigation into bacterial cyanogenesis from a medical viewpoint, despite the role P. aeruginosa plays in many serious infection settings and especially in CF lung disease. This review discusses the implications of cyanogenesis in the CF airway in terms of bacterial ecology, host immune response, progression of lung disease and potential treatment options
History
Publication title
Journal of Cystic FibrosisVolume
9Pagination
158-164ISSN
1569-1993Department/School
Tasmanian School of MedicinePublisher
Elsevier SciencePlace of publication
AmsterdamRepository Status
- Restricted