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Chronic obstructive pulmonary disease (COPD) is a major cause of chronic disability and mortality worldwide. Pathologically, it is a complex disease involving structural changes in lung parenchyma, airways, and vessels. Tissue remodeling is an integral part of COPD; nevertheless, published data on airway remodeling in particular in COPD are very limited. This review has summarized the available literature published during the last decade on structural changes in the airway component of the disease informed by major older publications. Available data show that COPD is quite different from asthma in regards to airway remodeling even when significant bronchodilator responses are present. The potential mechanisms of remodeling in COPD and its potential relationship with lung cancer are discussed.

Item Type:	Review Several Works
Research Division:	Medical and Health Sciences
Research Group:	Cardiorespiratory Medicine and Haematology
Research Field:	Respiratory Diseases
Objective Division:	Health
Objective Group:	Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:	Respiratory System and Diseases (incl. Asthma)
Author:	Soltani , A (Dr Amir Soltani Abhari)
Author:	Sohal, SS (Dr Sukhwinder Sohal)
Author:	Reid, D (Dr David Reid)
Author:	Wood-Baker, R (Professor Richard Wood-Baker)
Author:	Walters, EH (Professor Haydn Walters)
ID Code:	72616
Year Published:	2013
Deposited By:	Medicine (Discipline)
Deposited On:	2011-08-29
Last Modified:	2014-02-13
Downloads:	3 View Download Statistics