eCite Digital Repository
Tumour necrosis factor and Lymphotoxin: Molecular aspects and role in tissue-specific autoimmunity
Citation
Korner, H and Sedgwick, JD, Tumour necrosis factor and Lymphotoxin: Molecular aspects and role in tissue-specific autoimmunity, Immunology and Cell Biology, 74, (5) pp. 465-472. ISSN 0818-9641 (1996) [Refereed Article]
Abstract
Tumour necrosis factor (TNF) is a highly potent, proinflammatory cytokine with broad-ranging functions from the regulation of endothelial cell adhesion molecules to facilitate entry of leucocytes into tissues, to direct induction of cellular cytotoxicity. This diversity of function potentially attributable to TNF in the genesis of inflammatory disorders place TNF as a primary candidate for clinical targeting and considerable success in this regard has been achieved, particularly in rheumatoid arthritis (RA). In this article we provide a short overview of TNF and its homologue lymphotoxin (LT) α and β. Particular emphasis is placed on recent discoveries regarding the cell surface expression of these cytokines and the role of TNF/LT in experimental autoimmune encephalomyelitis (EAE), an animal model of the human demyelinating disease, multiple sclerosis (MS).
Item Details
Item Type: | Refereed Article |
---|---|
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Immunology |
Research Field: | Immunology not elsewhere classified |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Korner, H (Professor Heinrich Korner) |
ID Code: | 72568 |
Year Published: | 1996 |
Web of Science® Times Cited: | 60 |
Deposited By: | Research Division |
Deposited On: | 2011-08-29 |
Last Modified: | 2011-08-29 |
Downloads: | 0 |
Repository Staff Only: item control page