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Tumour necrosis factor and Lymphotoxin: Molecular aspects and role in tissue-specific autoimmunity
journal contribution
posted on 2023-05-17, 07:48 authored by Heinrich KornerHeinrich Korner, Sedgwick, JDTumour necrosis factor (TNF) is a highly potent, proinflammatory cytokine with broad-ranging functions from the regulation of endothelial cell adhesion molecules to facilitate entry of leucocytes into tissues, to direct induction of cellular cytotoxicity. This diversity of function potentially attributable to TNF in the genesis of inflammatory disorders place TNF as a primary candidate for clinical targeting and considerable success in this regard has been achieved, particularly in rheumatoid arthritis (RA). In this article we provide a short overview of TNF and its homologue lymphotoxin (LT) α and β. Particular emphasis is placed on recent discoveries regarding the cell surface expression of these cytokines and the role of TNF/LT in experimental autoimmune encephalomyelitis (EAE), an animal model of the human demyelinating disease, multiple sclerosis (MS).
History
Publication title
Immunology and Cell BiologyVolume
74Issue
5Pagination
465-472ISSN
0818-9641Department/School
Menzies Institute for Medical ResearchPublisher
Blackwell Publishing AsiaPlace of publication
54 University St, P O Box 378, Carlton, Australia, Victoria, 3053Repository Status
- Restricted