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Gene knock-out technology - a methodological overview for the interested novice
Citation
Gallitaliadoros, LA and Sedgwick, JD and Wood, SA and Korner, H, Gene knock-out technology - a methodological overview for the interested novice , Journal of Immunological Methods, 181, (1) pp. 1-15. ISSN 0022-1759 (1995) [Refereed Article]
DOI: doi:10.1016/0022-1759(95)00017-5
Abstract
Gene targeting by homologous recombination is a powerful technique, generating mouse strains with defined mutations in their genome. These genetically modified, 'designer' animals allow us for the first time to ask simple questions about elaborate and complex biological systems. Dissecting the function of individual components of the immune system is a perfect application of this technology. Although the techniques involved in the generation of gene knock-out mice are increasingly well defined, to many immunologists the language and concepts are confusing. This review presents the essentials of the technology in a form digestible by the non-expert. © 1995.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Immunology |
| Research Field: | Immunology not elsewhere classified |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Clinical health not elsewhere classified |
| UTAS Author: | Korner, H (Professor Heinrich Korner) |
| ID Code: | 72567 |
| Year Published: | 1995 |
| Web of Science® Times Cited: | 56 |
| Deposited By: | Research Division |
| Deposited On: | 2011-08-29 |
| Last Modified: | 2011-08-29 |
| Downloads: | 0 |
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