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Beta-1 Integrin Is Not Essential for Hematopoiesis but Is Necessary for the T Cell-Dependent IgM Antibody Response

Citation

Brakebusch, C and Fillatreau, S and Potocnik, AJ and Bungartz, G and Wilhelm, P and Svensson, M and Kearney, P and Korner, H and Gray, D and Fassler, R, Beta-1 Integrin Is Not Essential for Hematopoiesis but Is Necessary for the T Cell-Dependent IgM Antibody Response, Immunity, 16, (3) pp. 465-477. ISSN 1074-7613 (2002) [Refereed Article]

DOI: doi:10.1016/S1074-7613(02)00281-9

Abstract

Several experimental evidences suggested that β1 integrin-mediated adhesion of hematopoietic stem cells (HSC) is important for their function in the bone marrow (BM). Using induced deletion of the β1 integrin gene restricted to the hematopoietic system, we show that β1 integrin is not essential for HSC retention in the BM, hematopoiesis, and trafficking of lymphocytes. However, immunization with a T cell-dependent antigen resulted in virtually no IgM production and an increased secretion of IgG in mutant mice, while the response to a T cell-independent type 2 antigen showed decreases in both IgM and IgG. These data suggest that β1 integrins are necessary for the primary IgM antibody response.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Immunology
Research Field:Immunology not elsewhere classified
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Infectious Diseases
Author:Korner, H (Professor Heinrich Korner)
ID Code:72469
Year Published:2002
Web of Science® Times Cited:55
Deposited By:Research Division
Deposited On:2011-08-26
Last Modified:2011-08-29
Downloads:0

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