eCite Digital Repository

Membrane-bound TNF supports secondary lymphoid organ structure but is subservient to secreted TNF in driving autoimmune inflammation

Citation

Ruuls, SR and Hoek, RM and Ngo, VN and McNeil, T and Lucian, LA and Janatpour, MJ and Korner, H and Scheerens, H and Hessel, EM and Cyster, JG and McEvoy, LM and Sedgwick, JD, Membrane-bound TNF supports secondary lymphoid organ structure but is subservient to secreted TNF in driving autoimmune inflammation, Immunity, 15, (4) pp. 533-543. ISSN 1074-7613 (2001) [Refereed Article]

DOI: doi:10.1016/S1074-7613(01)00215-1

Abstract

Mice without secreted TNF but with functional, normally regulated and expressed membrane-bound TNF (memTNF╬"/╬" mice) were created by knocking-in the uncleavable ╬"1-9,K11E TNF allele. In contrast to TNF-deficient mice (TNF-/-), memTNF supported many features of lymphoid organ structure, except generation of primary B cell follicles. Splenic chemokine expression was near normal. MemTNF-induced apoptosis was mediated through both TNF-R1 and TNF-R2. That memTNF is suboptimal for development of inflammation was revealed in experimental autoimmune encephalomyelitis. Disease severity was reduced in memTNF╬"/╬" mice relative to wild-type mice, and the nature of spinal cord infiltrates resembled that in TNF-/- mice. We conclude that memTNF supports many processes underlying lymphoid tissue structure, but secreted TNF is needed for optimal inflammatory lesion development.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Immunology
Research Field:Immunology not elsewhere classified
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Infectious Diseases
Author:Korner, H (Professor Heinrich Korner)
ID Code:72465
Year Published:2001
Web of Science® Times Cited:189
Deposited By:Research Division
Deposited On:2011-08-26
Last Modified:2011-08-29
Downloads:0

Repository Staff Only: item control page