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Recirculating and marginal zone B cell populations can be established and maintained independently of primary and secondary follicles

Citation

Korner, H and Winkler, TH and Sedgwick, JD and Rollinghoff, M and Basten, A and Cook, MC, Recirculating and marginal zone B cell populations can be established and maintained independently of primary and secondary follicles, Immunology and Cell Biology, 79, (1) pp. 54-61. ISSN 0818-9641 (2001) [Refereed Article]

DOI: doi:10.1046/j.1440-1711.2001.00984.x

Abstract

In normal spleen, most recirculating naïve IgM +IgD hi B cells are located within primary follicles and mantle zones of secondary follicles. By contrast, the marginal zone contains a heterogeneous population of IgM hi- IgD lo/- B cells that are mostly non-recirculating. Although these are dynamic populations they are maintained at a constant size, the fundamental homeostatic mechanisms remain uncertain. One possibility is that the presence and turnover of each of the B cell populations is dependent on their location within discrete splenic compartments. To investigate this, we have characterized immature, non-recirculating, mature recirculating, marginal zone and B-1 cell populations in TNF -/- and TNF/lymphotoxin(LT)-α -/- mice that have disorganized splenic architecture. Labelling with 5-bromo-2′-deoxyuridine revealed that turnover of B cells in TNF -/- mice is normal, but is diminished in TNF/LT-α -/- mice. The recirculating B cell populations in both mutant strains are normal in proportion and phenotype. Marginal zone B cells are not seen in TNF/LT-α -/- mice, but this population appears normal in TNF -/- mice, even though they lack germinal centres. These findings indicate that peripheral B cell subsets can be established and maintained independently of normal follicular architecture.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Immunology
Research Field:Immunology not elsewhere classified
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Infectious Diseases
Author:Korner, H (Professor Heinrich Korner)
ID Code:72462
Year Published:2001
Web of Science® Times Cited:12
Deposited By:Research Division
Deposited On:2011-08-26
Last Modified:2011-08-29
Downloads:0

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